奥曲肽联合肠外营养对结直肠癌患者术后康复的疗效观察

The Efficacy Observation of Octreotide Combined with Parenteral Nutrition on Their Postoperative Rehabilitation of Colorectal Cancer Patients

目的:评价奥曲肽联合肠外营养对结直肠癌患者术后康复的效果。方法:将2021年6月至2022年11月,云浮市人民医院普通外科收治的54例腹腔镜结直肠癌根治术后患者随机分为观察组和对照组,各27例。观察组于术后2 h开始使用奥曲肽,术后24 h开始肠外营养。对照组术后24 h开始传统营养支持。比较2组营养状况、腹胀缓解有效率、胃肠功能恢复情况、住院时间及术后感染性并发症发生率等。结果:观察组术后第3、6天白蛋白、总蛋白含量均高于对照组(P<0.05);总有效率高于对照组(P<0.05);腹胀腹痛消失时间、首次排便时间和住院时间均明显短于对照组(P<0.05);术后感染性并发症发生率明显低于对照组(P<0.05)。结论:腹腔镜结直肠癌术后应用奥曲肽及肠外营养,可改善患者营养状况,减轻腹部症状,促进肛门排气,利于快速康复,减少术后并发症,值得临床推广应用。

Objective To investigate the efficacy of octreotide combined with parenteral nutrition on their postoperative rehabilitation of colorectal cancer patients. Methods Randomly divided 54 patients treated in authors' dept. and had received laparoscopic radical surgery for colorectal cancer(2021-06-2022-11) into observation group(27 cases, 2 hrs after surgery patients started to administere octreotide, and 24 hrs after surgery started to take parenteral nurition) and control group(27 cases, 24 hrs after surgery, started to take routine nutrition support);then, compared both groups' nutriture, the effective rate of burbulence relieved, the status on gastrointestinal function recovered, hospitalization duration, as well as the incidence of postoperative infectious complication, etc. Results In the levels of albumin(ALB) and total protein contents on the 3rd, 6th day;in total effective rate;in the time for burbulence and abdomen pain disappeared, for first defecation, and hospitalization, as well as in the incidence of postoperative infectious complication observation group was respectively higher;higher;shorter;as well as lower than control group(all, P<0.05). Conclusion After laparoscopic colorectal cancer surgery octreotide plus parenteral nutrition can improve patients' nutriture, relieve their abdominal symptoms, promote flatus from anus, reduce postoperative complication, and which is beneficial to fast rehabilitation, thus to be popularized to use clinically.