FLASH放疗研究现状的可视化分析

Visualization of the current research status of FLASH radiotherapy

目的基于科学期刊引文索引数据库(WOS),通过文献计量学方法对FLASH放疗领域的研究现状、热点和趋势进行可视化分析。方法以“(FLASH radiotherapy)OR(ultrahigh dose-rate radiotherapy)OR(FLASH irradiation)”为主题词,检索WOS数据库核心合集自建库至2022-01-18收录的FLASH放疗研究相关文献。运用WOS自带引文分析功能和CiteSpace 5.8.R3软件对纳入的文献发文趋势、发文国家、发文机构和研究热点进行可视化分析,绘制相应可视化知识图。结果共有144篇论文和22篇综述纳入分析,文献主要发表于2019-2021年,分别为22、48和76篇。发文量最多的国家是美国(61篇),中国发文量位居第7位(15篇)。发文量最多的研究机构是洛桑大学附属医院(15篇)。发文量最多的研究者是Vozenin MC(17篇)。研究热点以关键词形成8个聚类,分别为电子束、射线束、液态水、超高剂量率、质子治疗、放射治疗、免疫系统、电离室和临床前模型。FLASH放疗前沿集中于生物机制探讨、物理技术开发和FLASH放疗设备研发方面,FLASH放疗领域的趋势是向临床应用转化。结论FLASH放疗有望成为放射治疗领域革命性的新技术之一。这一技术的临床转化仍面临着诸多问题需要解决。我国学者应加强内部合作,积极与外部科研机构合作,促进该技术在临床中的安全转化。

Objective To visually analyze the current research status,hotspots and trends in the field of FLASH radiotherapy by bibliometric methods based on the web of science(WOS).Methods Using"FLASH radiotherapy OR ultrahigh dose-rate radiotherapy OR FLASH irradiation"as the subject terms,the relevant literature of FLASH radiotherapy were searched in the core collection of WOS database from the inception of database to January 18,2022.The included literature were visually analyzed the trend,country,institution of the publications and research hotspots using WOS self-contained citation analysis function and CiteSpace(5.8.R3)software.The corresponding visual knowledge map was drawn.Results A total of 144 articles and 22 reviews were included in the analysis,and the literature were mainly published in 2019-2021 with 22,48,and 76 papers published in each year,respectively.The United States has the largest number of papers published(61),and China ranks the seventh(15).The University Hospital of Lausanne published the largest number of papers(15).Vozenin MC published the most papers(17).Eight clusters were formed based on key words,including electron beams,beam,liquid water,ultra-high dose rate,proton therapy,radiation therapy,immune system,ionization chamber,preclinical models.The frontier of FLASH radiotherapy focused on the biological mechanism exploration,physical technology development and FLASH radiotherapy equipment development.The trend in the field of FLASH radiotherapy is to transform into clinical application.Conclusion FLASH radiotherapy is expected to be one of the revolutionary new techniques in radiotherapy.The clinical transformation of this technique still faces many problems to be solved.Chinese scholars should strengthen internal cooperation and actively cooperate with external scientific research institutions to promote the safe transformation of this technology in clinical practice.