交联透明质酸钠凝胶的使用时间对预防术后宫腔再粘连的疗效分析

Analysis of the Efficacy of Different Usage Time of Cross-Linked Sodium Hyaluronate for Preventing Postoperative Intrauterine Re-Adhesion.

目的探讨交联透明质酸钠凝胶的使用时间对预防中、重度宫腔粘连术后再次粘连的疗效的影响。方法采取前瞻性、随机对照研究方法,将2021年1月1日至2021年12月31日首次TCRA术后诊断为中、重度宫腔粘连的患者随机分为A组(在安置宫腔球囊时宫内注射1支交联透明质酸钠凝胶)和B组(在取出宫腔球囊后宫内注射1支交联透明质酸钠凝胶),对比两组患者术后1个月月经量改变的情况和宫腔形态恢复的情况。结果A、B两组治疗后月经量的改善率分别为100%、85%,差异有统计学意义(P<0.05);A组治疗后宫腔粘连范围和粘连类型的得分均低于B组,前者差异有统计学意义(P<0.05);后者差异无统计学意义(P>0.05)。结论安置宫腔球囊时使用交联透明质酸钠凝胶在短期随访中能更有效地改善月经量和宫腔粘连的范围。

Objective To investigate the effect of different usage time of cross-linked sodium hyaluronate for preventing intrauterine readhesion among the patients of moderate or severe intrauterine adhesion.Methods The prospective,randomized controlled trial included patients who were divided into group A,in which cross-linked sodium hyaluronate was applied before placing intrauterine balloon,and group B,in which hyaluronate was used after removing balloon.The menstrual changes and uterine morphology after one month of TCRA,during January to December 2021 were analyzed.Results The improvement rate of menstrual volume in group A and B was 100%and 85%,respectively,with significant differences(P<0.05).The scores of intrauterine adhesion range and adhesion type in group A were lower than those in group B after treatment,and the difference in group A was statistically significant(P<0.05).There was no statistical significance in the latter(P>0.05).Conclusion Usage of cross-linked sodium hyaluronate before placing uterine balloon can effectively improve menstrual volume and reduce intrauterine adhesive range in the short-term follow-up.