甲状腺癌中S100A6蛋白的表达意义

Significance of S100A6 Protein Expression in Thyroid Carcinoma

目的:探讨S100A6蛋白在甲状腺癌组织中的表达及临床意义,为临床评估病情提供有利依据。方法:选取本院2016年8月至2021年8月收治的120例甲状腺癌患者作为研究组,选取同期120例甲状腺良性结节患者作为对照组,取石蜡切片行免疫组织化学染色,检测S100A6蛋白的表达水平。结果:甲状腺良性结节与乳头状癌、髓样癌以及滤泡状癌在S100A6蛋白表达阳性率分别为12.50%、81.25%、30.00%和13.46%。由表2可见,通过两两比较发现,甲状腺良性结节与乳头状癌中,其阳性率经统计学分析有统计学意义(P<0.05);甲状腺良性结节与髓样癌的阳性率比较,经统计学分析有统计学意义(P<0.05);甲状腺良性结节与滤泡状癌阳性率比较,经统计学分析无统计学意义(P>0.05)。而甲状腺乳头状癌、髓样癌与滤泡状癌的阳性率比较,经统计学分析,有统计学意义(P<0.05)。结论:S100A6蛋白在甲状腺乳头状癌组织中高表达,可将其作为生物学的重要指标,同时S100A6蛋白也可作为甲状腺癌是否发生转移的预测指标。

Objective:To investigate the expression and clinical significance of S100A6 protein in thyroid carcinoma tissue,and to provide a favorable basis for clinical evaluation of the disease.Methods:One hundred and twenty patients with thyroid carcinoma admitted to our hospital from August 2016 to August 2021 were selected as the study group,and 120 patients with benign thyroid nodules in the same period were selected as the control group,and paraffin sections were taken for immunohistochemical staining to detect the expression level of S100A6 protein.Results:The positive rates of S100A6 protein expression were 12.50%,81.25%,30.00% and 13.46% in benign thyroid nodular,papillary thyroid carcinoma,medullary thyroid carcinoma and follicular carcinoma thyroid,respectively.As seen from Table 2,pairwise comparison showed that the positive rate of benign thyroid nodules and papillary thyroid carcinoma was statistically significant(P<0.05).The positive rate of benign thyroid nodules and medullary carcinoma was statistically significant(P<0.05).The comparison of the positive rate of benign thyroid nodules with follicular thyroid carcinoma was not statistically significant by statistical analysis(P>0.05).In contrast,the positive rate of papillary and medullary thyroid carcinoma compared with follicular thyroid carcinoma was statistically significant by statistical analysis(P<0.05).Conclusion:S100A6 protein is highly expressed in papillary thyroid carcinoma tissue,which can be used as an important biological indicator.At the same time,S100A6 protein can also be used as a predictor of thyroid carcinoma metastasis.