藏药防治高尿酸血症的机制及临床研究进展

Clinical Research Progress of Tibetan Medicine in Prevention and Treatment for Hyperuricemia

高尿酸血症是嘌呤代谢紊乱所致代谢性疾病,为痛风、高血压、糖尿病、心血管疾病和慢性肾脏疾病的独立危险因素。藏药因在防治高尿酸血症方面独具特色的方法和疗效,且毒副作用小,故倍受医药学界的关注。现代药理学研究表明,多种藏药方剂及单味药材可通过抑制黄嘌呤氧化酶活性、减少炎症因子表达和调整单胺类神经递质释放等方式发挥抗高尿酸血症作用。该文通过归纳总结现有文献,从藏医病因病机、临床用药及药效机制等方面对藏药防治高尿酸血症的研究进行综述,以期为其临床合理应用开发藏药提供参考。

Hyperuricemia is a metabolic disease caused by disordered purine metabolism,and it is an independent risk factor for gout,hypertension,diabetes,cardiovascular disease,and chronic kidney disease.Tibetan medicine has attracted much attention from the medical community because of its unique methods and efficacy in preventing and treating hyperuricemia,and its mild toxic and side effects.Modern pharmacological studies have shown that various Tibetan prescriptions and single medicinal herbs can play an anti-hyperuricemia role by inhibiting xanthine oxidase(XO)activity,reducing the expression of inflammatory factors,and adjusting the release of monoamine neurotransmitters.By summarizing the existing literature,the research on the prevention and treatment of hyperuricemia by Tibetan drugs from the aspects of Tibetan medical etiology,clinical medication,and efficacy mechanism is reviewed to provide a reference for its rational clinical application and development of Tibetan drugs.