茚达特罗联合盐酸溴己新治疗支气管扩张伴感染的临床疗效及对气道炎性反应缓解作用的影响

Clinical Efficacy of Indacaterol Combined with Bromohexine Hydrochloride in the Treatment of Bronchiectasis with Infection and its Effect on the Alleviation of Airway Inflammatory Response

目的研究茚达特罗联合盐酸溴己新治疗支气管扩张伴感染临床疗效及对气道炎性反应缓解作用的影响。方法选取2021年1月-2023年1月在我院诊治的60例支气管扩张伴感染患者为研究对象,采用随机数字表法分为对照组(30例)和观察组(30例),对照组采用盐酸溴己新治疗,观察组在对照组基础上联合茚达特罗治疗,比较两组临床疗效、临床症状缓解时间、痰液炎性指标[白细胞(WBC)、C反应蛋白(CRP)、中性粒细胞]、肺功能指标[用力肺活量(FVC)、第1 s用力呼气容积(FEV_(1))、FEV_(1)/FVC、最大呼气流量(PEF)]以及不良反应发生率。结果观察组治疗总有效率为90.00%,高于对照组的76.67%(P<0.05);观察组咳嗽、湿啰音、胸痛、口干、发热缓解时间均短于对照组(P<0.05);两组治疗后WBC、CRP、中性粒细胞水平均低于治疗前,且观察组低于对照组(P<0.05);治疗后观察组FVC、FEV_(1)、FEV_(1)/FVC、PEF均高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论茚达特罗联合盐酸溴己新治疗支气管扩张伴感染具有理想的效果,可快速缓解临床症状,减轻气道炎性反应,促进肺功能指标恢复,且不会增加不良反应,有利于患者的快速康复,值得临床应用。

Objective To investigate the clinical efficacy of indacterol combined with bromohexine hydrochloride in the treatment of bronchiectasis with infection and its effect on the alleviation of airway inflammatory response.Methods From January 2021 to January 2023,60 patients with bronchiectasis and infection diagnosed and treated in our hospital were selected as the research objects.They were divided into control group(30 patients)and observation group(30 patients)by random number table method.The control group was treated with bromhexine hydrochloride,and the observation group was treated with indacaterol on the basis of the control group.The clinical efficacy,remission time of clinical symptoms,sputum inflammatory indexes[white blood cell(WBC),C-reactive protein(CRP),neutrophils],lung function indexes[forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),FEV_(1)/FVC,maximum expiratory flow(PEF)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.00%,which was higher than 76.67%in the control group(P<0.05).The remission time of cough,moist rale,chest pain,dry mouth and fever in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of WBC,CRP and neutrophils in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,FVC,FEV_(1),FEV_(1)/FVC and PEF in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Indacaterol combined with bromhexine hydrochloride has a ideal effect in the treatment of bronchiectasis with infection,which can quickly relieve clinical symptoms,reduce airway inflammation,promote the recovery of lung function indicators,and will not increase adverse reactions.Meanwhile,it is conducive to the rapid recovery of patients and is worthy of clinical application.