左氧氟沙星联合氨溴索治疗老年慢性阻塞性肺疾病合并肺部感染患者的疗效研究

Study on efficacy of levofloxacin combined with ambroxol on elderly patients with chronic obstructive pulmonary disease and pulmonary infection

目的探究左氧氟沙星联合氨溴索治疗老年慢性阻塞性肺疾病(COPD)合并肺部感染患者的临床疗效。方法40例老年COPD合并肺部感染患者,随机分为观察组和对照组,各20例。对照组患者采用盐酸左氧氟沙星治疗,观察组患者在对照组基础上采用盐酸氨溴索注射液治疗。比较两组治疗后生化指标[白细胞计数(WBC)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、载脂蛋白E(ApoE)]、影像学肺病灶吸收时间和住院时间。结果治疗后,观察组患者的WBC(7.41±2.15)×10^(9)/L、PCT(0.52±0.17)ng/ml、hs-CRP(24.38±9.25)mg/L、ApoE(41.05±9.82)mg/L均显著低于对照组的(10.03±3.14)×10^(9)/L、(1.13±0.32)ng/ml、(43.74±11.67)mg/L、(61.06±13.26)mg/L,差异均有统计学意义(P<0.05)。观察组患者的影像学肺病灶吸收时间(7.24±2.25)d和住院时间(11.46±3.08)d均短于对照组的(12.08±2.76)、(18.06±3.67)d,差异均有统计学意义(P<0.05)。结论左氧氟沙星联合氨溴索治疗老年COPD合并肺部感染患者的疗效显著,可明显改善生化指标,为临床提供一种安全、有效、可靠的治疗方式。

Objective To investigate the clinical efficacy of levofloxacin combined with ambroxol on elderly patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.Methods A total of 40 elderly patients with COPD and pulmonary infection were randomly divided into observation group and control group,with 20 cases in each group.The control group was treated with levofloxacin hydrochloride,and the observation group was treated with ambroxol hydrochloride injection based on the control group.Both groups were compared in terms of biochemical indices[white blood cell count(WBC),procalcitonin(PCT),highsensitivity C-reactive protein(hs-CRP),aplipoprotein E(ApoE)]after treatment,the absorption time of imaging lung lesions,and the length of hospital stay.Results After treatment,the observation group had WBC of(7.41±2.15)×10^(9)/L,PCT of(0.52±0.17)ng/ml,hs-CRP of(24.38±9.25)mg/L,and ApoE of(41.05±9.82)mg/L,which were significantly lower than those of(10.03±3.14)×10^(9)/L,(1.13±0.32)ng/ml,(43.74±11.67)mg/L,and(61.06±13.26)mg/L in the control group,and the differences were statistically significant(P<0.05).The absorption time of imaging lung lesions of(7.24±2.25)d and the length of hospital stay of(11.46±3.08)d in the observation group were shorter than those of(12.08±2.76)and(18.06±3.67)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Levofloxacin combined with ambroxol is effective in the treatment of elderly patients with COPD and pulmonary infection,which can significantly improve the biochemical indexes and provide a safe,effective and reliable clinical treatment modality.