补锌辅助西米替丁治疗对轮状病毒性肠炎患儿临床疗效、血清炎性因子及心肌酶谱指标水平的影响

Effect of zinc supplementation with cimetidine on clinical efficacy,serum inflammatory factors and myocardial enzymes indexes in children with rotavirus enteritis

目的探究补锌辅助西米替丁治疗对轮状病毒性肠炎患儿临床疗效、血清炎性因子和心肌酶谱指标的影响。方法80例轮状病毒性肠炎患儿,采取抽签法分为对照组和研究组,每组40例。对照组采用西米替丁治疗,研究组采用补锌辅助西米替丁治疗。比较两组患儿的临床疗效,血清炎性因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素(IL-6)]及心肌酶谱指标[血清乳酸脱氢酶(LDH)、磷酸肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)]水平。结果研究组患儿的治疗总有效率为95.00%(38/40),高于对照组的77.50%(31/40),差异具有统计学意义(P<0.05)。治疗后,研究组患儿的CRP、PCT、IL-6水平分别为(6.82±1.35)mg/L、(0.36±0.11)μg/L、(27.63±5.74)ng/L,均明显低于对照组的(8.25±1.73)mg/L、(1.20±0.28)μg/L、(34.25±4.69)ng/L,差异具有统计学意义(P<0.05)。治疗后,研究组患儿的LDH、CK-MB、AST水平分别为(90.78±11.36)、(31.21±6.29)、(22.15±4.08)U/L,均明显低于对照组的(118.49±12.06)、(46.62±6.73)、(28.72±4.30)U/L,差异具有统计学意义(P<0.05)。结论补锌辅助西米替丁治疗可以有效改善轮状病毒性肠炎患儿炎性反应,减少对患儿造成的心肌损伤,是提高轮状病毒性肠炎患儿临床疗效的一种有效治疗方案。

Objective To investigate the effect of zinc supplementation with cimetidine on clinical efficacy,serum inflammatory factors and myocardial enzymes indexes in children with rotavirus enteritis.Methods A total of 80 children with rotavirus enteritis were divided into control group and research group by lottery method,with 40 cases in each group.The control group was treated with cimetidine,and the research group was treated with zinc supplementation and cimetidine.Both groups were compared in terms of clinical efficacy,serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),interleukin(IL-6)]and myocardial enzyme indexes[serum lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST)].Results The total effective rate was 95.00%(38/40)in the research group,which was higher than that of 77.50%(31/40)in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,PCT and IL-6 in the research group were(6.82±1.35)mg/L,(0.36±0.11)μg/L and(27.63±5.74)ng/L,which were significantly lower than those of(8.25±1.73)mg/L,(1.20±0.28)μg/L and(34.25±4.69)ng/L in the control group,and the differences were statistically significant(P<0.05).After treatment,LDH,CK-MB and AST levels in the research group were(90.78±11.36),(31.21±6.29)and(22.15±4.08)U/L,which were significantly lower than those of(118.49±12.06),(46.62±6.73)and(28.72±4.30)U/L in the control group,and the differences were statistically significant(P<0.05).Conclusion Zinc supplementation with cimetidine can effectively improve the inflammatory response of children with rotavirus enteritis and reduce myocardial damage to children,and is an effective treatment plan to improve the clinical efficacy of children with rotavirus enteritis.