他汀类药物与依折麦布联合应用于老年冠心病并血脂异常患者中的效果研究

Study on the effect of statins combined with ezetimibe in elderly patients with coronary heart disease and dyslipidemia

目的:评价他汀类药物联合依折麦布对老年冠心病并血脂异常的治疗效果。方法:选择2020年7月至2021年7月在本院医治冠心病并血脂异常的120例老年患者,应用随机数字表法分为对照组和研究组各60例。对照组单用阿托伐他汀钙片,研究组联用阿托伐他汀钙片与依折麦布片。组间对比临床疗效和不良反应发生率,同时对比治疗前后的甘油三酯、高密度脂蛋白、低密度脂蛋白、总胆固醇。结果:研究组的总有效率(90.00%)高于对照组(66.67%),统计学对比有差异(χ^(2)=9.624,P=0.002<0.05)。研究组的不良反应发生率(10.00%)低于对照组的15.00%,统计学对比无明显差异(P>0.05)。对比给药前的四项血脂指标,统计学对比无明显差异(χ^(2)=0.686,P=0.408>0.05);给药后进行对比,两组的四项血脂指标均发生改变,且除了高密度脂蛋白研究组高于对照组,其他三项血脂指标均为研究组低于对照组,统计学对比有差异(P<0.05)。结论:联用阿托伐他汀钙片与依折麦布片治疗老年冠心病并血脂异常可获得显著疗效和安全性,患者的血脂水平可以得到更加显著的改善。

Objective:To evaluate the therapeutic ffct of statins combined with ezetimibe on elderly patients with coronary heart disease complicated with dyslipidemia.Methods:A total of 120 elderly patients with coronary heart disease and dyslipidemia who were treated in our hospital from July 2020 to July 2021 were selected and divided into the control group and the study group with 60 cases in each group by random number table method.The control group was given atorvastatin calcium tablet alone,while the study group was given atorvastatin calcium tablet combined with ezetimibe tablet.The clinical efficacy and incidence of adverse reactions were compared bet ween groups,and triglyceride,high-density lipoprotein,low-density lipoprotein,and total cholesterol before and after treatment were compared.Results:The total effective rate(90.00%)of the study group was higher than that of the control group(66.67%),and there was a statistical difference(χ^(2)=9.624,P=0.002-0.05).The incidence of adverse reactions in the study group(10.00%)was lower than 15.00%in the control group,and there was no statistical difference(P>0.05).Comparing the four blood lipid indexes before administration,there was no statistical difference(χ^(2)=0.686,P=0.408>0.05);after administration,the four blood lipid indexes in the two groups were changed.The high-density lipoprotein of research group was higher than the control group,and the other three blood lipid indexes were all lower than the control group,with statist ical differences(P<0.05).Conclusion:Combined use of atorvastatin calcium tablets and ezetimibe tablets in the treatment of elderly patients with coronary heart disease complicated with dyslipidemia can achieve significant efficacy and safety,and the blood lipid levels of patients can be significantly improved.