中药小分子抑制新生血管形成机制的研究进展

Small molecules of traditional Chinese medicine inhibiting neovascularization:research progress on mechanism

一系列中药复方在临床实践和基础实验中被证明能够抑制病理性新生血管形成。中药小分子是中药复方中实际发挥药效的活性成分,特定中药小分子通过不同途径抑制血管内皮细胞生长因子的表达,从而抑制新生血管形成,为相关血管新生疾病的治疗提供了新思路。新生血管形成在糖尿病性视网膜病变等视网膜新生血管疾病中扮演了重要的角色,也对恶性肿瘤的发生、发展具有重要作用。本文概述了新生血管形成的过程和机制,并以黄酮类、皂苷类、生物碱等中药小分子为主,讨论了中药小分子抑制新生血管形成的机制。

A series of traditional Chinese medicine decoction have been proved to inhibit pathological neovascularization in both clinical practice and laboratory experiment.Small molecules of traditional Chinese medicine are the active components of compound decoction of traditional Chinese medicine.Some small molecules of traditional Chinese medicine can inhibit neovascularization by suppressing the expression of vascular endothelial cell growth factors in different ways,which provides new ideas for the treatment of angiogenesis diseases.Neovascularization plays an important role not only in retinal angiogenesis diseases such as diabetic retinopathy,but also in the development and progression of malignant tumors.In this review,the process and the mechanism of neovascularization were briefly described,and the mechanisms of inhibiting neovascularization by flavonoids,saponins,alkaloids and other small molecules of traditional Chinese medicine were reviewed in detail.