乳腺癌骨转移研究进展——从基础到临床

Research Progress on Bone Metastasis of Breast Cancer:from Basic to Clinical Research

骨骼是晚期乳腺癌最好发的转移部位,骨转移所致骨相关事件严重影响患者的生存质量及生存期。因此,提高乳腺癌骨转移患者的生存质量、延长其生存时间,深入探究骨转移的发生发展机制、探索早期诊断方法、寻找有效的骨转移治疗方法和药物具有重要临床意义。本文主要从分子机制、影像学及生物学诊断方法、系统治疗等方面对乳腺癌骨转移的相关最新研究进展进行阐述,以期为临床诊治提供参考。

Bone is the most common metastatic site of advanced breast cancer.Bone related events caused by bone metastasis seriously affect the quality of life and survival time of patients.Therefore,in order to improve the quality of life and prolong the survival time of breast cancer patients with bone metastases,it is of great clinical value to investigate the occurrence and development mechanism of bone metastases,explore early diagnosis methods,and pursue abundant and effective treatment methods and drugs for bone metastases.This article mainly reviews the new research progress of bone metastasis of breast cancer from the aspects of molecu⁃lar mechanism,imaging and biological diagnosis methods,systematic treatment,in order to provide more ref⁃erence for clinical diagnosis and treatment.