先天性腹膜鞘状突未闭疾患与ABO血型的相关性

Correlation between congenital patent processus vaginalis and ABO blood group

目的探讨先天性腹膜鞘状突未闭(PPV)疾患与ABO血型的相关性。方法回顾性分析2003年1月至2021年12月该院收治的1128例存在PPV疾患儿童(病例组)的临床资料和同期收治的4208例其他疾病儿童(对照组)的临床资料。病例组根据疾病类型分为腹股沟斜疝组(738例)、精索鞘膜积液组(228例)和隐睾组(162例)。比较各组患儿ABO血型分布情况。结果腹股沟斜疝组患儿中A、B、O、AB型血分别占28.3%(209/738)、28.5%(210/738)、28.7%(212/738)、14.5%(107/738),对照组患儿中A、B、O、AB型血分别占29.9%(1257/4208)、29.4%(1237/4208)、22.6%(949/4208)、18.2%(765/4208),2组患儿血型构成比较,差异有统计学意义(P<0.05)。A、B、AB型血儿童较O型血儿童患腹股沟斜疝风险低[优势比(OR)=0.744、0.760、0.626,95%可信区间(95%CI):0.604~0.917、0.617~0.936、0.487~0.805,P=0.006、0.010、<0.001]。调整年龄、性别、民族等影响因素后O型血儿童患腹股沟斜疝的风险较非O型血高(OR=1.396,95%CI:1.160~1.679,P<0.001),AB型血儿童患腹股沟斜疝的风险较非AB型血低(OR=0.742,95%CI:0.590~0.934,P=0.011)。结论该院所诊治的儿童病例中因先天性PPV发生腹股沟斜疝与ABO血型可能存在相关性,ABO血型为小儿腹股沟斜疝发生的一个影响因素。

Objective To investigate the correlation between congenital patent processus vaginalis(PPV)disease and ABO blood group.Methods The retrospective analysis was performed on the clinical data of 1128 children patients(case group)with PPV admitted and treated in this hospital from January 2003 to December 2021 and 4208 children cases of other diseases(control group)at the same time.According to the disease type,the case group was divided into the indirect inguinal hernia group(738 cases),spermatic cord hydrocele group(228 cases)and cryptorchidism group(162 cases).The ABO blood group distribution situation was compared among the groups.Results The A,B,O and AB blood groups in the indirect inguinal hernia group accounted for 28.3%(209/738),28.5%(210/738),28.7%(212/738)and 14.5%(107/738)respectively,which in the control group accounted for 29.9%(1257/4208),29.4%(1237/4208),22.6%(949/4208)and 18.2%(765/4208)respectively.The blood group constitution had statistically significant difference between the two groups(P<0.05).The risk of indirect inguinal hernia in children with type A,B and AB blood groups was lower than that in children with type O blood group[odds ratio(OR)=0.744(95%CI:0.604-0.917,P=0.006),0.760(95%CI:0.617-0.936,P=0.010),0.626(95%CI:0.487-0.805,P=0.000)],respectively.After adjusting the influencing factors such as the age,sex and nationality,the risk of suffering from indirect inguinal hernia in the children with type O blood group was higher than that in the children with non-type O blood group[OR=1.396(95%CI):1.160-1.679,P<0.001],and the risk of indirect inguinal hernia in the children with type AB blood was lower than that in the children with non-type AB blood group[OR=0.742(95%CI:0.590-0.934),P=0.011].Conclusion Among the children patients diagnosed and treated in this hospital,there is a possible correlation between indirect inguinal hernia occurrence due to congenital PPV and ABO blood group and ABO blood group is an influencing factor for indirect inguinal hernia occurrence in children.