血清25-羟维生素D3、白介素-6水平与儿童热性惊厥的临床分析

Clinical analysis between serum 25-hydroxyvitamin D3,interleukin⁃6 levels and febrile convulsion in children

目的:探讨儿童热性惊厥与25-羟维生素D3[25-(OH)D3]、白介素-6(IL-6)水平的关系。方法:热性惊厥组选取2017年01月~2022年10月就诊于海南省妇女儿童医学中心确诊为热性惊厥的241例患儿(分为单纯性热性惊厥和复杂性热性惊厥);对照组为就诊于海南省妇女儿童医学中心门诊进行体检、无不适症状的100名健康儿童。所有入组儿童进行血清25-(OH)D3水平、IL-6水平测定,并录入年龄、性别、季节等临床信息。结果:(1)热性惊厥组血清25-(OH)D3水平明显低于健康对照组[分别是(78.77±20.37)nmol/L与(96.55±29.74)nmol/L],两组的差异具有统计学意义(t=−6.359,P<0.001)。热性惊厥组血清IL-6水平明显高于健康对照组,两组的差异具有统计学意义(Z=−14.291,P<0.001)。(2)复杂性热性惊厥儿童血清25-(OH)D3水平明显低于单纯性热性惊厥儿童,两组的差异具有统计学意义(t=6.612,P<0.05)。复杂性热性惊厥儿童IL-6水平高于单纯性热性惊厥儿童,两组的差异具有统计学意义(Z=−10.151,P<0.001)。热性惊厥的严重程度在血清25-(OH)D3水平上的差异有统计学意义(χ2=29.83,P<0.001)。(3)相关性分析结果显示,血清25-(OH)D3水平与热性惊厥呈负相关(γ=−0.393,P<0.05);而血清IL-6水平与其呈正相关(γs=0.328,P<0.05)。(4)热性惊厥儿童在不同季节的血清25-(OH)D3水平无统计学差异(P>0.05)。结论:热性惊厥与血清25-(OH)D3、IL-6的水平存在相关性,25-(OH)D3与IL-6可能参与热性惊厥的发病机制。

Objective:To investigate the relation between febrile convulsions and 25-hydroxyvitamin D3[25(-OH)D3]and interleukin-6(IL-6)levels in children.Methods:241 children(divided into simple febrile convulsions and complex febrile convulsions),who were diagnosed with febrile convulsions at the Hainan Women and Children's Medical Center from January 2017 to October 2022,were selected into the febrile convulsions group;100 healthy children,who had no uncomfortable symptoms and attended the outpatient clinic of the Hainan Women and Children's Medical Center for physical examination,were included into the control group.For all the subjects,the serum 25-(OH)D3 and IL-6 levels were measured,and clinical information,such as age,gender and season,was recorded.Results:(1)Serum 25-(OH)D3 levels in the febrile convulsion group were significantly lower than in the healthy control group[(78.77±20.37)nmol/L versus(96.55±29.74)nmol/L,respectively],and there was a statistically significance between the two groups(t=−6.359,P<0.001).Serum IL-6 levels in the febrile convulsion group were significantly higher than in the healthy control group,and there was a statistically significance between the two groups(Z=−14.291,P<0.001).(2)Serum 25-(OH)D3 levels in children with complex febrile convulsions were significantly lower than those in children with simple febrile convulsions,and the difference between the two groups was statistically significant(t=of 6.612,P<0.05).IL-6 levels were higher in children with complex febrile convulsions than in children with simple febrile convulsions,and the difference between the two groups was statistically significant(Z=−10.151,P<0.001).The difference in the severity of febrile convulsions was statistically significant in serum 25-(OH)D3 levels(χ^(2)=29.83,P<0.001).(3)The results of correlation analysis showed that serum 25-(OH)D3 level was negatively correlated with febrile convulsion(γ=−0.393,P<0.05).However,serum IL-6 levels were positively correlated with it(γs=0.328,P<0.05).(4)In contrast,there was no statistically significant difference in serum 25-(OH)D3 levels among children with febrile convulsions in different seasons(P>0.05).Conclusion:There is a correlation between febrile convulsion and serum levels of 25-(OH)D3 and IL-6.25(-OH)D3 and IL-6 may participate in the pathogenesis of febrile convulsion.