免疫检查点分子在妊娠中的研究进展

Research progress of immune checkpoint molecules in pregnancy

近年来免疫检查点分子在诱导移植耐受、肿瘤免疫逃避和预防自身免疫等领域取得了突破性进展。这些免疫调节因子与配体结合后能够转导抑制信号到细胞内负性调节免疫反应,这为妊娠及妊娠并发症的免疫研究带来了新的启示。本文就目前主要免疫检查点分子CTLA-4、PD-1和Tim-3在妊娠中的免疫调节作用作一综述,以帮助评估其在妊娠中的潜在效用,以期为妊娠并发症的免疫治疗提供新的方向。

In recent years,immune checkpoint molecules have made breakthroughs in the fields of inducing graft tolerance,tumor immune escape and preventing autoimmunity.These immunoregulatory factors,when combined with ligand,can transduce the inhibitory signal into cells to negatively regulate the immune response,which brings new enlightenment for the im-mune research of pregnancy and pregnancy complications.In this review,we reviewed the immunomodulatory effects of CTLA-4,PD-1 and Tim-3 in pregnancy,in order to evaluate their potential effects in pregnancy,and to provide a new direction for the im-munotherapy of pregnancy complications.