基于N,N-二乙基苯胺BODIPY光敏剂的构筑与光热性能探究

Construction and Photothermal Performance of BODIPY Photosensitizer Based on N,N-diethylaniline

利用Knoevenagel缩合反应合成了基于N,N-二乙基苯胺的BODIPY衍生物光敏剂,并对光敏剂的结构、单线态氧产生能力、光热性能、光热转换效率和光稳定性进行了探究.实验结果表明,该光敏剂具有较好的光稳定性和抗光漂白性,产生单线态氧的能力强,光热活性优异,光热转换效率可达40.72%,有望用于肿瘤的光动力治疗和光热治疗.

BODIPY derivative photosensitizer based on N,N-diethylaniline was synthesized by Knoevenagel condensation reaction.The structure,singlet oxygen generation capacity,photothermal performance,photothermal conversion efficiency and photostability of photosensitizer were investigated.The results showed that the photosensitizer had good photostability and photobleaching resistance,strong ability to generate singlet oxygen,excellent photothermal activity,and the photothermal conversion efficiency could reach 40.72%.Consequently,the photosensitizer is expected to be used in photodynamic therapy and photothermal therapy of tumors.