Optic neuritis after mRNA vaccination against COVID-19:a secondary analysis of post-approval national safety data by the Japanese government

Optic neuritis after mRNA vaccination against COVID-19:a secondary analysis of post-approval national safety data by the Japanese

Vaccination is the mainstream measure against coronavirus disease 2019(COVID-19).As of May 2022,more than 80%of the Japanese population has received vaccination doses(1),and booster vaccination programs are in progress.Acute disseminated encephalomyelitis is the most common type of demyelination following vaccinations,and although an increase in neuromyelitis optica spectrum disease(NMOSD)has recently been reported worldwide(2-4),no collective data,especially after newly developed mRNA vaccines against COVID-19,have been reported yet.