阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究

Association between sleep efficiency and diabetes mellitus in obstructive sleep apnea syndrome and primary snoring patients

目的分析睡眠效率在阻塞性睡眠呼吸暂停(obstructive sleep apnea syndrome,OSA)和单纯鼾症患者中与糖尿病(diabetes mellitus,DM)患病率的相关性。方法以2002年10月至2021年9月在首都医科大学宣武医院呼吸科睡眠医学中心接受睡眠监测的3124例患者为研究对象。所有患者根据睡眠效率比例不同分为≥85%、80%~84.9%和<80%三个等级,并以呼吸暂停低通气指数(apnea hypopnea index,AHI)≥5次/h将纳入患者分为OSA组及单纯鼾症组,以多因素Logistic模型分析睡眠效率与DM之间的相关性。结果在OSA组患者中,校正潜在混杂因素后,与睡眠效率≥85%相比,睡眠效率<80%者发生DM的概率明显升高(OR=1.563,95%CI:1.005~2.431,P=0.047),而在单纯鼾症组差异无统计学意义(OR=0.957,95%CI:0.509~1.799,P=0.891)。结论在OSA患者中,睡眠效率低的患者糖尿病的发生风险明显增加,而在单纯鼾症患者中差异无统计学意义。

Objective To investigate the association between sleep efficiency and diabetes mellitus(DM)in obstructive sleep apnea syndrome(OSA)and primary snoring patients.Methods A total of 3124 patients who received sleep monitoring in the Sleep Medical Center of Xuanwu Hospital,Capital Medical University from October 2002 to September 2021 were retrospectively analyzed.Sleep efficiency was divided into grade 1(≥85%),grade 2(80%-84.9%),and grade 3(<80%).All participants were divided into OSA group and simple snoring group with apnea hypopnea index(AHI)≥5 times/h.Multivariate Logistic regression models were utilized to investigate the association between sleep quality and diabetes mellitus.Results In OSA patients,after adjusting for potential confounding factors,compared with sleep efficiency≥85%,the prevalence of DM in sleep efficiency<80%group was significantly higher(OR=1.563,95%CI:1.005-2.431,P=0.047),but there was no significant difference in primary snoring group(OR=0.957,95%CI:0.509-1.799,P=0.891).Conclusion There is a significant correlation between poor sleep efficiency and the incidence of DM in OSA patients.