宫颈上皮内瘤变小鼠模型构建的研究进展

Research progress in the establishment of mouse models of cervical intraepithelial neoplasia

现存关于宫颈上皮内瘤变(cervical intraepithelial neoplasia, CIN)的治疗多以手术为主,临床诊治方面缺乏特效治疗药物。手术虽能清除已转化病灶,但残端在病毒及其他因素的持续作用下仍具有病变风险,因此CIN的预防与治疗研究仍需要合适的动物模型作为支撑。宫颈病变通常表现为一系列连续性过程,这种渐进性病变方式为构建动物模型带来一定困难。国内外关于CIN动物模型的构建研究近年来逐渐增加,本文通过论述CIN小鼠模型的研制方法及优缺点,以期为构建更为适合的动物模型提供思路,以及对宫颈上皮内瘤变的远期防治策略及用药研究提供助力。

Cervical intraepithelial neoplasia is mostly treated by surgery,and clinically specific drugs are lacking.Although surgery can remove transformed lesions,the stump has the risk of lesions under the continuous action of viruses and other factors.Therefore,prevention and treatment of CIN require suitable animal models.Cervical lesions usually manifest as a series of continuous processes,and this progressive pathological process makes it difficult to replicate in animal models.Research on the establishment of CIN animal models at home and abroad has gradually increased in recent years.This review discusses the development method,advantages,and disadvantages of CIN mouse models to provide ideas for the establishment of more suitable animal models and long-term prevention and treatment of cervical intraepithelial neoplasia.Strategy and drug research to provide assistance.