阿替普酶联合替罗非班对急性脑梗死患者的治疗效果研究

Study on the Treatment Effect of Alteplase Combined with Tirofiban in Patients with Acute Cerebral Infarction

目的 探究阿替普酶联合替罗非班对急性脑梗死患者的治疗效果。方法 随机选取韶关市第一人民医院2017年1月—2021年1月收治的60例急性脑梗死患者为研究对象,采用随机数表法分为对照组(采用阿替普酶治疗)和观察组(采用阿替普酶联合替罗非班治疗),每组30例,比较两组患者治疗前后的神经功能、认知功能、血浆黏度及临床结局。结果 观察组治疗1周、5周后的神经功能评分分别为(9.19±1.52)分、(7.21±1.32)分,均低于对照组,差异有统计学意义(t=9.304、6.497,P<0.05)。观察组治疗1周、治疗5周后的认知功能评分分别为(21.09±2.61)分、(28.17±3.27)分,均高于对照组,差异有统计学意义(t=6.429、2.676,P<0.05)。观察组治疗5 d后血浆黏度(1.85±0.21)mPa·s低于对照组患者,差异有统计学意义(t=5.628,P<0.05)。观察组治疗后临床结局(1.58±0.41)分优于对照组,差异有统计学意义(t=5.506,P<0.05)。结论 阿替普酶联合替罗非班对老年急性脑梗死患者的治疗效果良好,不仅可以提高患者神经功能恢复的速度,调节患者认知功能,增加血液流变学水平,还可改善临床结局。

Objective To investigate the therapeutic effect of alteplase combined with tirofiban on patients with acute cerebral infarction.Methods 60 patients with acute cerebral infarction admitted to the First People's Hospital of Shaoguan City from January 2017 to January 2021 were randomly selected as the study objects.By random number table method,they were divided into control group(treated with alteplase)and observation group(treated with alteplase combined with tirofiban),with 30 cases in each group.Neurological function,cognitive function,plasma viscosity and clinical outcome were compared between the two groups before and after treatment.Results The neurological function scores of the observation group after 1 week and 5 weeks were(9.19±1.52)points and(7.21±1.32)points,respectively,which were lower than those of the control group,and the difference was statistically significant(t=9.304,6.497,P<0.05).The cognitive function scores of the observation group were(21.09±2.61)points and(28.17±3.27)points after 1 and 5 weeks of treatment,respectively,which were higher than those of the control group,and the difference was statistically significant(t=6.429,2.676,P<0.05).After 5 days of treatment,the plasma viscosity of observation group(1.85±0.21)mPa·s was lower than that of control group,and the difference was statistically significant(t=5.628,P<0.05).The clinical outcome of the observation group(1.58±0.41)points was better than that of the control group,and the difference was statistically significant(t=5.506,P<0.05).Conclusion Alteplase combined with tirofiban has a good therapeutic effect on elderly patients with acute cerebral infarction,which can not only improve the speed of neurological recovery,regulate the cognitive function of patients,increase the level of hemorheology,but also improve the clinical outcome.