妊娠期女性发生低甲状腺素血症的特征及妊娠结局分析

Characteristics of Hypothyroxinemia in Pregnant Women and Analysis of Pregnancy Outcome

目的 基于Logistic回归分析探讨影响妊娠期女性发生低甲状腺素血症的相关因素。方法 回顾性选取2019年12月—2021年12月陆军第七十三集团军医院产科收治的148例妊娠期女性的临床资料,根据其是否发生低甲状腺素血症分为发生组(n=40例)和未发生组(n=108例)。记录纳入对象的临床资料,采用单因素析和多因素Logistic回归分析妊娠期女性低甲状腺素血症发生的相关因素,并比较两组不良妊娠率。结果 在本研究148例妊娠期女性中,有40例发生低甲状腺素血症占比27.03%,108例未发生低甲状腺素血症占比72.97%;单因素分析结果显示,体质指数(BMI)、既往流产史、摄入碘含量、摄入铁含量、血脂水平与妊娠期女性发生低甲状腺素血症有关(P<0.05);经过多因素Logistic回归分析系统可得出BMI(OR=5.303)、既往流产史(OR=5.658)、摄入碘含量(OR=12.349)、摄入铁含量(OR=9.667)、血脂水平(OR=3.492)均是妊娠期女性发生低甲状腺素血症的相关因素(OR>1,P<0.05);两组不良妊娠率对比,差异有统计学意义(P<0.05)。结论 妊娠期女性发生低甲状腺素血症,主要与其高BMI、既往有流产史、缺碘、缺铁、血脂异常有关系,且会影响到其妊娠结局。

Objective Exploring the relevant factors affecting the occurrence of hypothyroidism in pregnant women based on logistic regression analysis.Methods Clinical data of 148 pregnant women admitted to the Obstetrics and Gynecology Department of the 73rd Group Military Hospital of the Army from December 2019 to December 2021 were retrospectively selected.They were divided into an incidence group(n=40 cases)and a non incidence group(n=108 cases)based on whether they had developed hypothyroidism.Record the clinical data of the included subjects,use univariate analysis and multivariate logistic regression to analyze the related factors of hypothyroidism in pregnant women,and compare the adverse pregnancy rates between the two groups.Results Among 148 pregnant women in this study,40(27.03%)developed hypothyroidism,while 108(72.97%)did not;the results of univariate analysis showed that body mass index(BMI),previous miscarriage history,iodine intake,iron intake,and blood lipid levels were associated with the occurrence of hypothyroidism in pregnant women(P<0.05);through a multivariate logistic regression analysis system,it can be concluded that BMI(OR=5.303),previous miscarriage history(OR=5.658),iodine intake(OR=12.349),iron intake(OR=9.667),and blood lipid levels(OR=3.492)are all related factors for the occurrence of hypothyroidism in pregnant women(OR>1,P<0.05);the difference in adverse pregnancy rates between the two groups was statistically significant(P<0.05).Conclusion The occurrence of hypothyroidism in pregnant women is mainly related to high BMI,previous history of miscarriage,iodine deficiency,iron deficiency,and abnormal blood lipids,and can affect their pregnancy outcomes.