屈螺酮炔雌醇片(Ⅱ)与炔雌醇环丙孕酮片治疗多囊卵巢综合征的效果对比

Comparison of the Effects of Drospirenone and Ethinylestradiol Tablets and Ethinylestradiol Cyproterone Tablets in the Treatment of Polycystic Ovarian Syndrome

目的 对屈螺酮炔雌醇片(Ⅱ)与炔雌醇环丙孕酮片治疗多囊卵巢综合征的效果分析。方法 随机抽取2020年1月—2021年1月间广汉市妇幼保健院收治的多囊卵巢综合征患者60例为研究对象,并按照随机数字表法分为对照组及研究组,各30例。对照组采用炔雌醇环丙孕酮片进行治疗,研究组采用屈螺酮炔雌醇片(Ⅱ)治疗,对比两组胰岛素、血脂、激素水平。结果 治疗后,研究组服用75 g葡萄糖后1、2、3 h的胰岛素水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组高密度脂蛋白、三酰甘油水平高于对照组,低密度脂蛋白水平低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组黄体生成素、促卵泡激素/黄体生成素均低于对照组,差异有统计学意义(P<0.05)。研究组睾酮(1.51±0.34)nmol/L低于对照组(1.76±0.37)nmol/L,差异有统计学意义(t=2.725,P=0.009)。结论 对多囊卵巢综合征患者实施屈螺酮炔雌醇片(Ⅱ)进行治疗的价值较高,可以显著改善患者的雌激素水平。

Objective To analysis the effect of drospirenone ethinylestradiol tablets(Ⅱ)and ethinylestradiol cyproterone tablets on polycystic ovary syndrome.Methods Sixty patients with polycystic ovary syndrome admitted to Guanghan Maternal and Child Health Hospital from January 2020 to January 2021 were randomly selected as the study subjects,and were randomly divided into a control group and a study group by random number table method,with 30 patients in each group.The control group was treated with ethinylestradiol cyproterone tablets,and the study group was treated with drospirenone ethinylestradiol tablets(II).The insulin,blood lipid,and hormone levels of the two groups were compared.Results After treatment,the insulin levels of the study group at 1 hours,2 hours,and 3 hours after taking 75 g of glucose were higher than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of high-density lipoprotein and triacylglycerol in the study group were higher than those in the control group,and the levels of low-density lipoprotein were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of luteinizing hormone and follicle stimulating hormone/luteinizing hormone in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The testosterone levels in the study group(1.51±0.34)nmol/L were lower than those in the control group(1.76±0.37)nmol/L,and the difference was statistically significant(t=2.725,P=0.009).Conclusion Drospirenone ethinylestradiol tablets(Ⅱ)is of high value in the treatment of patients with polycystic ovary syndrome,which can significantly improve the estrogen level of patients.