复合凝乳酶胶囊联合四联活菌片治疗小儿功能性消化不良的效果分析

Effect Analysis of Compound Rennet Capsules Combined with Quadruple Viable Bacteria Tablets in the Treatment of Functional Dyspepsia in Children

目的分析复合凝乳酶胶囊与四联活菌片联合治疗小儿功能性消化不良(functional dyspepsia,FD)的疗效。方法方便选取2018年3月—2021年10月大冶市人民医院儿内科收治的小儿功能性消化不良患儿300例,根据随机数表法分为两组,各150例。对照组给予常规疗法和四联活菌片治疗,观察组在此基础上给予复合凝乳酶胶囊治疗,对比两组的总有效率、临床症状积分、细胞因子水平、胃排空指标及胃肠激素指标。结果观察组患儿的总有效率(96.00%)高于对照组(88.0%),差异有统计学意义(χ^(2)=6.522,P<0.05);观察组患儿治疗2周后的临床症状积分、血清IL-6水平和血清TNF-α水平均低于对照组,差异有统计学意义(P<0.001);观察组患儿治疗后的胃排空时间短于对照组,而胃窦收缩幅度和收缩次数均高于对照组,差异有统计学意义(P<0.001);观察组治疗后的血浆胃动素水平高于对照组,血浆生长抑素水平低于对照组,差异有统计学意义(P<0.001);观察组的不良反应发生率(4.00%)与对照组的不良反应发生率(3.33%)比较,差异无统计学意义(χ^(2)=0.094,P>0.05)。结论复合凝乳酶胶囊与四联活菌片联合治疗小儿FD疗效肯定,促进患儿胃肠激素水平恢复正常,抑制炎症反应,改善胃肠动力,值得推广。

Objective To analyze the curative effect of Compound Rennet Capsules and Quadruple Viable Bacteria Tablets in the treatment of functional dyspepsia(FD)in children.Methods A total of 300 children with functional dyspepsia were conveniently selected from the Department of Pediatrics of the hospital from March 2018 to October 2021.According to the random number table method,they were divided into two groups,each with 150 cases.The control group was treated with conventional therapy and quadruple viable bacteria tablets,and the observation group was treated with compound rennet capsules on this basis.The total effective rate,clinical symptom scores,cytokines level and cytokine levels gastric emptying indicators and gastrointestinal hormones were compared between the two groups.Results The total effective rate of the observation group(96.00%)was higher than that of the control group(88.0%),the difference was statistically significant(χ^(2)=6.522,P<0.05).And after 2 weeks of treatment,the clinical symptom score,serum IL-6 level and serum TNF-αlevel of the observation group were lower than those of the control group,the difference was statistically significant(P<0.001).The gastric emptying time after treatment in the observation group was shorter than that in the control group,while the gastric antrum contraction amplitude and contraction times were higher than those in the control group,the difference was statistically significant(P<0.001).After treatment,the plasma motilin level of the observation group was higher than that of the control group,and the plasma somatostatin level was lower than that of the control group,the difference was statistically significant(P<0.001).There was no significant difference between the incidence of adverse reactions in the observation group(4.00%)and control group(3.33%)(χ^(2)=0.094,P>0.05).Conclusion The combination of compound rennet capsules and Quadruple living bacteria tablets has a positive effect on children with FD.It can promote the recovery of gastrointestinal hormone levels in children,inhibit inflammation,and improve gastrointestinal motility.It is worth popularizing.