尤瑞克林联合阿替普酶溶栓对急性脑梗死的作用

Effect of Urinary Kallidinogenase Combined with Alteplase Thrombolysis on Acute Cerebral Infarction

目的分析尤瑞克林联合阿替普酶溶栓对急性脑梗死的作用。方法选取2020年1—12月吉林省神经精神病医院收治的急性脑梗死患者66例为研究对象,以随机数表法分为对照组(尤瑞克林治疗)和观察组(尤瑞克林联合阿替普酶溶栓治疗),各33例,观察两组治疗效果。结果治疗后,观察组hs-CRP(9.82±0.70)mg/L、IL-1β(11.20±2.78)pg/mL、TNF-α(13.62±1.24)pg/mL均低于对照组,差异有统计学意义(t=13.580、26.119、38.999,P<0.05)。治疗后,相比于对照组,观察组MFV(78.96±5.47)cm/s、BHI(0.92±0.10)较高,PI(0.58±0.04)较低,差异有统计学意义(t=8.153、3.416、8.074,P<0.05)。治疗7、14 d后,相比于对照组,观察组NIHSS评分较低,BI评分较高,差异有统计学意义(P<0.05);CSS评分较对照组低,但差异无统计学意义(P>0.05)。观察组总有效率高于对照组,差异有统计学意义(χ^(2)=7.543,P<0.05)。观察组肌力恢复情况优于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.606,P>0.05)。结论急性脑梗死患者实施尤瑞克林联合阿替普酶溶栓治疗,能够改善患者血清炎性因子、脑血管储备功能、神经系统缺损与日常生活能力,提高治疗效果。

Objective To analyze the effect of Urinary Kallidinogenase combined with Alteplase Thrombolysis on acute cerebral infarction.Methods From January to December 2020,66 patients with acute cerebral infarction admitted to Jilin Provincial Neuropsychiatric Hospital were selected as the study subject.They were randomly divided into a control group(treatment with Urinary Kallidinogenase)and an observation group(treatment with Urinary Kallidinogenase and Ateplase)using a random number table method,with 33 patients in each group.The therapeutic effects of the two groups were observed.Results After treatment,in the observation group,hs-CRP(9.82±0.70)mg/L,IL-1β(11.20±2.78)pg/mL、TNF-α(13.62±1.24)pg/mL were lower than those in the control group,and the difference was statistically significant(t=13.580,26.119,38.999,P<0.05).After treatment,compared with the control group,the MFV(78.96±5.47)cm/s,BHI(0.92±0.10),in the observation group were higher and PI(0.58±0.04),was lower,the difference was statistically significant(t=8.153,3.416,8.074,P<0.05).After 7 d and 14 d of treatment,compared with the control group,the NIHSS score in the observation group was lower and the BI score was higher,the difference was statistically significant(P<0.05);the CSS score was lower than that of the control group,but the difference was not statistically significant(P>0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(χ^(2)=7.543,P<0.05).The recovery of muscle strength in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.606,P>0.05).Conclusion Urinary Kallidinogenase combined with Alteplase Thrombolysis therapy in patients with acute cerebral infarction can improve serum inflammatory factors,cerebrovascular reserve function,nervous system defects and daily living ability of patients,and improve the therapeutic effect.