奥氮平与阿立哌唑治疗精神分裂症的临床有效性研究

Clinical Efficacy of Olanzapine and Aripiprazole in the Treatment of Schizophrenia

目的探析应用奥氮平与阿立哌唑联合治疗精神分裂症的有效性、安全性。方法选取2019年1月—2021年5月麻城市精神病医院收治的60例精神分裂症患者为研究对象,根据治疗方法不同分为两组,每组30例。对照组应用奥氮平治疗,观察组应用奥氮平与阿立哌唑联合治疗。治疗3个月后,对比两组患者的治疗效果。结果治疗后,观察组脑源性神经营养因子(BDNF)(19.66±1.83)ng/mL、个人与社会功能量表(PSP)评分(79.67±7.68)分,高于对照组(16.51±1.54)ng/mL、(71.40±6.68)分,S100钙结合蛋白B(S1OOB)(0.29±0.03)ng/mL、阳性和阴性症状量表(PANSS)评分(2.90±0.31)分,低于对照组(0.41±0.05)ng/mL、(3.60±0.50)分,差异有统计学意义(t=7.214、4.363、11.261、6.562,P<0.05)。观察组治疗总有效率(96.67%)高于对照组(66.67%),不良反应发生率(6.67%)低于对照组(26.67%),差异有统计学意义(χ^(2)=9.017、4.320,P<0.05)。结论奥氮平与阿立哌唑联合治疗精神分裂症效果较好,能有效地缓解患者的临床症状,在提高其疗效和生活质量的同时,还可以减少不良反应的发生。

Objective To explore the efficacy and safety of olanzapine combined with aripiprazole in the treatment of schizophrenia.Methods A total of sixty patients with schizophrenia admitted to Macheng Psychiatric Hospital from January 2019 to May 2021 were selected as the study objects and divided into two groups according to different treatment methods,30 cases in each group.The control group were treated with olanzapine,and the observation group were treated with olanzapine combined with aripiprazole.After 3 months of treatment,the treatment efficacy of the two groups were compared.Results After treatment,brain-derived neurotrophic factor(BDNF)(19.66±1.83)ng/mL,Personal and Social Performance scale(PSP)(79.67±7.68)points in the observation group were higher than the control group(16.51±1.54)ng/mL,(71.40±6.68)points,S100 calcium binding protein B(S100B)(0.29±0.03)ng/mL,Positive and Negative Symptom Scale(PANSS)(2.90±0.31)points were lower than(0.41±0.05)ng/mL,(3.60±0.50)points in the control group,and the difference was statistically significant(t=7.214,4.363,11.261,6.562,P<0.05).The total treatment effective rate of the observation group(96.67%)was higher than that of the control group(66.67%),and the incidence of adverse reactions(6.67%)was lower than that of the control group(26.67%),the difference was statistically significant(χ^(2)=9.017,4.320,P<0.05).Conclusion The combination of olanzapine and aripiprazole in the treatment of schizophrenia has a good effect,can effectively relieve the clinical symptoms of patients,improve the efficacy and quality of life while also reducing the occurrence of adverse reactions.