盐酸苯海索片联合盐酸司来吉兰片治疗帕金森病的效果

Effect of Trihexyphenidyl Hydrochloride Tablets Combined with Selegiline Hydrochloride Tablets in the Treatment of Parkinson's Disease

目的 对帕金森病患者采用盐酸苯海索片联合盐酸司来吉兰片治疗的效果进行探究。方法 随机选择2020年1月—2021年6月单县中心医院收治的90例帕金森病患者,根据患者所接受的治疗方案不同平均分。甲组(45例)接受盐酸司来吉兰片治疗,乙组(45例)则在甲组的基础之上接受盐酸苯海索片治疗。对比两组的治疗效果、SCOPA-AUT评分、MMSE评分、UPDRS评分、氧化应激指标。结果乙组的总有效率(97.78%)高于甲组(80.00%),差异有统计学意义(χ^(2)=7.200,P<0.05)。治疗后,乙组的SCOPA-AUT评分、UPDRS评分、MMSE评分低于甲组,NOS、SOD、PON1、CGP等氧化应激指标高于甲组,差异有统计学意义(P<0.05)。结论 在治疗帕金森患者时,联合应用盐酸苯海索及盐酸司来吉兰能够达到很好的治疗效果,可以快速缓解各项症状,提高神经功能及认知功能,还可以改善机体抗氧化应激能力。

Objective To investigate the therapeutic effect of benhexol hydrochloride combined with selegiline hydrochloride tablets on Parkinson's disease patients.Methods A total of 90 Parkinson's disease patients admitted to the Single County Central Hospital from January 2020 to June 2021 were selected randomly,and they were evenly divided according to the different treatment plans they received.Group A(45 cases)received treatment with selegiline hydrochloride tablets,while group B(45 cases)received treatment with benhexol hydrochloride tablets on top of group A.Compared the treatment efficacy,SCOPA-AUT score,MMSE score,UPDRS score,and oxidative stress indicators between the two groups.Results The total effective rate of group B(97.78%)was higher than that of group A(80.00%),and the difference was statistically significant(χ^(2)=7.200,P<0.05).After treatment,the SCOPA-AUT score,UPDRS score,and MMSE score of group B were lower than those of group A,while oxidative stress indicators such as NOS,SOD,PON1,CGP were higher than those of group A,and the difference was statistically significant(P<0.05).Conclusion When treating Parkinson's patients,the combination of benhexol hydrochloride and selegiline hydrochloride can achieve good therapeutic effects,quickly alleviate various symptoms,improve neurological and cognitive functions,and also improve the body's antioxidant stress capacity.