产前硫酸镁和地塞米松干预治疗对早产儿结局的影响

Effect of Prenatal Magnesium Sulfate and Dexamethasone Intervention on the Outcome of Premature Infants

目的 探析产前硫酸镁和地塞米松干预治疗对早产儿结局的影响。方法 方便选取2020年2月—2021年2月昆明市妇幼保健院收治的早产儿92例进行研究,按照产前孕妇治疗方式将其分为两组,产前孕妇应用利托君和地塞米松进行治疗分娩的46例早产儿纳入参比组,产前孕妇应用硫酸镁和地塞米松进行治疗分娩的46例早产儿纳入观察组。分析两组的治疗有效率、早产儿不良结局、出生48 h后的血流动力学指标水平、出生1年后的发育商评分、神经系统评分。结果 治疗后,观察组的治疗有效率为97.83%,高于参比组的82.61%,差异有统计学意义(χ^(2)=4.433,P=0.035);观察组的早产儿不良结局优于参比组,差异有统计学意义(P<0.05);观察组出生48 h后的血流动力学指标水平优于参比组,差异有统计学意义(P<0.05);观察组出生1年后的发育商评分为(89.28±4.23)分、神经系统评分为(28.27±0.52)分,均高于参比组,差异有统计学意义(t=4.176、18.182,P<0.05)。结论 对早产情况产前应用硫酸镁和地塞米松干预治疗的效果较好,能够提高治疗有效率,改善早产儿不良结局,优化血流动力学指标,利于新生儿健康成长。

Objective To explore the effect of prenatal magnesium sulfate and dexamethasone intervention on the outcome of premature infants.Methods 92 cases of premature infants admitted to Kunming Maternal and Child Health Hospital from February 2020 to February 2021 were conveniently selected for study,and they were divided into two groups according to prenatal treatment for pregnant women.46 premature infants treated with ritodrine and dexamethasone were included in the reference group,and 46 premature infants treated with magnesium sulfate and dexamethasone were included in the observation group.The effective rate of treatment,adverse outcome of premature infants,hemodynamic index level 48 h after birth,developmental quotient score 1 year after birth,and nervous system score of the two groups were analyzed.Results After treatment,the effective rate of the observation group was 97.83%higher than that of the reference group 82.61%,and the difference was statistically significant(χ^(2)=4.433,P=0.035);the adverse outcome of preterm infants in the observation group was better than that in the reference group,and the difference was statistically significant(P<0.05);the hemodynamic index level of the observation group was better than that of the reference group 48 hours after birth,and the difference was statistically significant(P<0.05);one year after birth,the developmental quotient score(89.28±4.23)points and nervous system score(28.27±0.52)points in the observation group were higher than those in the reference group,and the difference was statistically significant(t=4.176,18.182,P<0.05).Conclusion Prenatal intervention of magnesium sulfate and dexamethasone in premature births has a good effect,which can improve the effective rate of treatment,improve the adverse outcome of premature infants,optimize the hemodynamic indexes,and facilitate the healthy growth of newborns.