盐酸多奈哌齐治疗急性脑梗死后认知障碍的临床疗效

Clinical Efficacy of Donepezil Hydrochloride in Treating Cognitive Impairment After Acute Cerebral Infarction

目的 分析盐酸多奈哌齐治疗急性脑梗死后认知障碍患者的临床疗效,确定盐酸多奈哌齐应用价值。方法 将2020年3月—2021年3月入院接受治疗且符合纳入与排除标准的急性脑梗死后认知障碍患者作为本研究对象,共56例。将住院编号为单数的患者纳入至研究组,双号则纳入至对照组,每组各28例。两组急性脑梗死后认知障碍患者均行基础治疗,其中对照组在基础上开展奥拉西坦治疗,研究组则在基础上进行盐酸多奈哌齐治疗。比较治疗后两组患者认知、精神、生活等能力恢复情况、血清学相关指标以及治疗效果、并发症发生率。结果 治疗前两组急性脑梗死后认知障碍患者的相关指标差异无统计学意义(P> 0.05),治疗后两组患者的各项指标均较治疗前出现改善,患者病情出现恢复,研究组急性脑梗死后认知障碍患者的蒙特利尔认知评估量表(Montreal cognitive assessment,Mo CA)、简易精神状况检查量表(mini-mental state examination,MMSE)、Barthel指数(barthel index,BI)评分显著高于对照组;超敏-C反应蛋白、白介素-6、肿瘤坏死因子-α水平明显低于对照组,差异有统计学意义(P <0.05)。研究组治疗效果优于对照组,恶心、头晕、腹泻发生率则低于对照组,但差异无统计学意义(P> 0.05)。结论 盐酸多奈哌齐治疗急性脑梗死后认知障碍患者的临床疗效确切。

Objective To analyze the clinical efficacy of donepezil hydrochloride in patients with cognitive impairment after acute cerebral infarction and determine the application value of donepezil hydrochloride.Methods A total of 56 patients with cognitive impairment after acute cerebral infarction who were admitted for treatment from March 2020 to March 2021 and met the inclusion and exclusion criteria were selected as subjects of this study.The hospitalization number singular patients into the study group,double number into the control group,with 28 cases in each group.Two groups of acute cerebral infarction after cognitive impairment are basic treatment,the control group on the basis of oracetam treatment,research group is on the basis of donepeperzil hydrochloride treatment.After treatment,the recovery of cognitive,mental,life and other abilities,serological indicators,therapeutic effect and complication rate of the two groups were compared.Results There was no significant difference in the relevant indexes of patients with cognitive impairment after acute cerebral infarction before treatment(P>0.05).After treatment,all the indexes of the two groups were improved compared with those before treatment,and the patients’condition recovered.Montreal cognitive assessment scale(MoCA),mini-mental state examination(MMSE)and barthel index(BI)score were significantly higher than those of the control group.The levels of hypersensitive C-reactive protein,interleukin-6 and tumor necrosis factor-αwere significantly lower than the control group,and the difference was statistically significant(P<0.05).The therapeutic effect was better than the control group.The incidence of nausea,dizziness and diarrhea was lower than the control group,but the difference was not statistically significant(P>0.05).Conclusion The clinical efficacy of donepezil hydrochloride in patients with cognitive impairment after acute cerebral infarction is definite.