独活寄生汤治疗类风湿关节炎患者的效果分析

Analysis of the Effect of Duhuo Jisheng Decoction on Rheumatoid Arthritis Patients

目的 探究独活寄生汤治疗类风湿关节炎患者的临床效果。方法 选取长春中医药大学附属医院风湿科2019年6月—2022年6月收治的78例类风湿关节炎患者开展研究,随机抽签法分为对照组(予以常规对症治疗)、观察组(在常规对症治疗基础上予以独活寄生汤),每组各39例,治疗为期1个月,对比临床疗效,包括临床总有效率、实验室检查结果、病情恢复情况及用药安全性。结果 用药1个月后,观察组总有效率(94.87%)高于对照组(79.49%)(P <0.05);观察组血清白细胞介素-1β(interleukin,IL-1β)、白细胞介素-6(interleukin,IL-6)、血清肿瘤坏死因子-α(tumor necrosis factor,TNF-α)浓度及中医症候积分低于对照组(P <0.05);两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论 独活寄生汤的临床疗效显著,利于调节患者血清IL-1β、IL-6及TNF-α水平,改善病情,缓解症状,以及减少不良反应。

Objective To explore the clinical effect of Duhuo Jisheng decoction on rheumatoid arthritis patients.Methods A total of 78 patients with rheumatoid arthritis admitted to department of rheumatology,the Affiliated Hospital of Changchun University of Traditional Chinese Medicine from June 2019 to June 2022 were selected for the study.They were randomly divided into the control group(treated with routine symptomatic treatment)and the observation group(treated with Duhuo Jisheng decoction on the basis of routine symptomatic treatment)with 39 cases in each grou for 1 month.Clinical efficacy was compared,including total clinical effective rate,laboratory test results,disease recovery and drug safety.Results After one month of medication,the total effective rate of the observation group(94.87%)was higher than that of the control group(79.49%)(P<0.05).Serum interleukin-1β(IL-1β),interleukin-6(IL-6),serum tumor necrosis factor-α(TNF-α)and the concentration and TCM symptom score in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Duhuo Jisheng decoction has a significant clinical effect,which is beneficial to regulate the levels of serum IL-1β、IL-6 and TNF-α,improve the condition,relieve symptoms,and reduce adverse reactions.