摘要
二甲双胍是公认治疗2型糖尿病(T2DM)的一线药物,近年来,多项研究表明二甲双胍在包括子宫内膜癌(EC)、宫颈癌(CC)和卵巢癌(OC)等在内的多种恶性病变中具有抗肿瘤作用,从而提高妇科恶性肿瘤患者术后生存期。因此,深入探讨二甲双胍在妇科恶性肿瘤中的潜在作用对临床恶性肿瘤的辅助治疗具有重要意义。本文通过查阅大量文献,阐述其在不同妇科恶性肿瘤中的作用机制及应用疗效,为临床妇科恶性肿瘤治疗提供借鉴。
Metformin is a widely recognized first-line drug for the treatment of type 2 diabetes mellitus(T2DM).In recent years,a number of studies have shown that metformin has antitumor effects in a variety of malignant lesions,including endometrial cancer(EC),cervical cancer(CC)and ovarian cancer(OC),thus improving postoperative survival of patients with gynecological malignant tumors.Therefore,it is of great significance to investigate the potential role of metformin in gynecological malignancies for adjuvant treatment of clinical malignancies.Through reviewing a large number of literatures,this paper expounds its mechanism and therapeutic effect in different gynecological malignant tumors,providing reference for the clinical treatment of gynecological malignant tumors.
作者
刘晓
岳玲
马杏
李玉兰
许飞雪
LIU Xiao;YUE Ling;MA Xing;LI Yulan;XU Feixue(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Department of Obstetrics and Gynecology,First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)
出处
《中国性科学》
2023年第5期87-91,共5页
Chinese Journal of Human Sexuality
基金
甘肃省科技计划项目(21JR7RA378)。
关键词
二甲双胍
恶性肿瘤
宫颈癌
子宫内膜癌
卵巢癌
Metformin
Malignant tumor
Cervical cancer
Endometrial cancer
Ovarian cancer
