我国宫颈癌患者性功能障碍患病率的Meta分析

Meta analysis of the prevalence of sexual dysfunction in patients with cervical cancer in China

目的系统评价我国宫颈癌患者性功能障碍(SD)的患病率,为宫颈癌患者性健康研究提供数据支持。方法在Web of Science、PubMed、Embase、CNKI、CBM、万方、维普等数据库中检索我国宫颈癌患者SD患病率的原始文献,检索时限截止2022年2月,以Stata 15.0软件开展Meta分析。结果共纳入18项研究,涉及2709例患者。Meta分析显示,我国宫颈癌患者SD总患病率是76%(95%CI:69%~83%)。亚组分析显示,年龄≥40岁和<40岁宫颈癌患者SD患病率分别为80%(95%CI:73%~88%)和51%(95%CI:32%~70%);初中及以下和高中及以上宫颈癌患者SD患病率分别为69%(95%CI:57%~81%)和33%(95%CI:5%~61%);肿瘤分期为Ⅰ期、Ⅱ期及Ⅲ期宫颈癌患者SD患病率分别为56%(95%CI:46%~65%)、76%(95%CI:71%~81%)及78%(95%CI:62%~93%);治疗方案为手术治疗与非手术治疗的宫颈癌患者SD患病率分别是72%(95%CI:63%~82%)和79%(95%CI:75%~84%);东部、中部和西部地区宫颈癌SD患病率分别为75%(95%CI:62%~88%)、81%(95%CI:72%~89%)和68%(95%CI:48%~88%)。结论我国宫颈癌患者SD患病率较高,在制定治疗方案时可考虑将性健康咨询作为整体癌症治疗的一部分。

Objective To systematically evaluate the prevalence of sexual dysfunction(SD)in patients with cervical cancer in China,and to provide data support for the study of sexual health in patients with cervical cancer.Methods The original literatures on the prevalence of SD among patients with cervical cancer in China was searched in Web of Science,PubMed,Embase,CNKI,CBM,Wanfang,VIP and other databases until February 2022.The Stata 15.0 software was used for meta analysis.Results 18 literatures involving 2709 patients were finally included.Meta analysis showed that the total prevalence of SD in patients with cervical cancer in China was 76%(95%CI:69%-83%).Subgroup analysis showed that the prevalence of SD in patients aged≥40 years and<40 years was 80%(95%CI:73%-88%)and 51%(95%CI:32%-70%)respectively;the prevalence rates of SD in cervical cancer patients with junior middle school and below and senior high school and above education were 69%(95%CI:57%-81%)and 33%(95%CI:5%-61%)respectively;the prevalence of SD in patients with stageⅠ,stageⅡand stageⅢcervical cancer were 56%(95%CI:46%-65%),76%(95%CI:71%-81%)and 78%(95%CI:62%-93%)respectively;the prevalence of SD in cervical cancer patients treated with surgery and non-surgical treatment were 72%(95%CI:63%-82%)and 79%(95%CI:75%-84%)respectively;the prevalence of SD in cervical cancer in eastern,central and western regions were 75%(95%CI:62%-88%),81%(95%CI:72%-89%)and 68%(95%CI:48%-88%)respectively.Conclusions The prevalence of SD in cervical cancer patients in China is high.Sexual health counseling can be considered as a part of overall cancer treatment when formulating treatment plans.