慢性心力衰竭伴高尿酸血症与血压变异性的关系及特点

Relationship between Hyperuricemia and Blood Pressure Variability in Chronic Heart Failure

目的:探讨慢性心力衰竭(CHF)伴高尿酸血症(HUA)患者的血压变异性特点,并分析尿酸与血压变异性指标的相关性。方法:选取南方医科大学顺德医院附属杏坛医院2022年2月至2022年10月收治的100例CHF患者作为研究对象,根据患者是否合并HUA分为CHF组(无HUA)与CHF+HUA组,检测并比较两组患者尿酸、N末端B型利钠肽原(NT–proBNP)、血压变异性指标[(24 h收缩压(SBP)、24 h舒张压(DBP)、日间(d)SBP、dDBP、夜间(n)SBP、nDBP、24hSBP–标准差(sd)、24hDBP–sd、dSBP–sd、dDBP–sd、nSBP–sd、nDBP–sd)]的差异。采用Spearman相关分析尿酸与NT–proBNP、24hSBP、24hDBP、dSBP、dDBP、nSBP、nDBP、24hSBP–sd、24hDBP–sd、dSBP–sd、dDBP–sd、nSBP–sd、nDBP–sd的相关性。结果:CHF+HUA组患者的尿酸、NT–proBNP、全部血压变异性指标均显著高于CHF组患者,差异均具有统计学意义(P<0.05)。Spearman相关性分析发现,CHF+HUA组患者尿酸与NT–proBNP、全部血压变异性指标均呈正相关(r>0,P<0.05)。结论:CHF伴HUA患者血压变异性指标均显著高于无HUA的CHF患者,尿酸升高可导致CHF患者的血压异常,临床上对CHF患者应密切检测尿酸并积极处理以改善其预后。

Objective To investigate the characteristics of blood pressure variability in patients with chronic heart failure(CHF)and hyperuricemia(HUA),and to analyze the correlation between uric acid and blood pressure variability.Methods A total of 100 patients with CHF admitted to Xingtan Hospital,Shunde Hospital of Southern Medical University from February 2022 to October 2022 were selected as research objects,and divided into CHF group(without HUA)and CHF+HUA group according to whether the patients had HUA.Uric acid,N-terminal B-type natriuretic peptide(NT-proBNP),blood pressure variability index[(24 hours systolic blood pressure(SBP),24 hours diastolic blood pressure(DBP),daytime(d)SBP,dDBP,night(n)SBP,nDBP,24h SBP standard deviation(sd),24h DBP-sd,dDBP-sd,dDBP-sd,nSBP-sd,nDBP-sd)].Spearman correlation was used to analyze uric acid and NT-proBNP,24h SBP,24h DBP,dSBP,dDBP,nSBP,nDBP,24h SBP-sd,24h DBP-sd,dSBP-sd,dDBP-sd,nSBP-sd,nDBP-sd.Results The uric acid,NT-proBNP and all blood pressure variability indexes in CHF+HUA group were significantly higher than those in CHF group,with statistical significance(P<0.05).Spearman correlation analysis showed that uric acid was positively correlated with NT-proBNP and all indexes of blood pressure variability in CHF+HUA group(r>0,P<0.05).Conclusion The blood pressure variability indexes in CHF patients with HUA were significantly higher than those in CHF patients without HUA.Elevated uric acid can lead to abnormal blood pressure in CHF patients.In clinical practice,uric acid should be closely detected and actively treated to improve the prognosis of CHF patients.