人免疫球蛋白联合注射用头孢哌酮钠舒巴坦钠在NIP中的应用效果

Application Effect of Human Immunoglobulin Combined with Cefoperazone Sodium for Injection and Sulbactam Sodium in neonatal infectious pneumonia

目的:探究人免疫球蛋白联合注射用头孢哌酮钠舒巴坦钠在新生儿感染性肺炎(NIP)中的应用效果。方法:选取莆田市儿童医院2021年4月至2022年4月收治的40例NIP患儿作为研究对象,以随机数字表法分组,分为对照组和观察组,各20例。对照组行注射用头孢哌酮钠舒巴坦钠治疗,观察组行人免疫球蛋白联合注射用头孢哌酮钠舒巴坦钠治疗。比较两组患儿临床症状消失时间、血清炎症因子水平、治疗效果。结果:(1)临床症状消失时间:呼吸困难时间、咳嗽消失时间、肺音消失时间、体温稳定时间、喘息消失时间比较,观察组患儿均短于对照组,差异具有统计学意义(P<0.05)。(2)血清炎症因子水平:治疗前,两组患儿降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿各项血清炎症因子水平均低于对照组,差异具有统计学意义(P<0.05)。(3)治疗效果:观察组患儿治疗有效率高于对照组,差异具有统计学意义(P<0.05)。结论:对NIP患儿实行人免疫球蛋白联合注射用头孢哌酮钠舒巴坦钠治疗,能有效缩短患儿的呼吸困难时间、咳嗽消失时间、肺音消失时间、体温稳定时间、喘息消失时间,调节血清炎症因子水平。

Objective To explore the application effect of human immunoglobulin combined with cefoperazone sodium and sulbactam sodium for injection in neonatal infectious pneumonia(NIP).Methods Forty NIP children admitted to Putian Children's Hospital from April 2021 to April 2022 were selected as research objects,and divided into a control group and an observation group by random number table method,with 20 cases in each group.The control group was treated with cefoperazone sodium and sulbactam sodium for injection,and the observation group was treated with pedestrian immunoglobulin combined with cefoperazone sodium and sulbactam sodium for injection.The disappearance time of clinical symptoms,serum inflammatory factor levels and therapeutic effect were compared between the two groups.Results(1)Disappearance time of clinical symptoms:dyspnea time,cough disappearance time,pulmonary rales disappearance time,temperature stability time,wheezing disappearance time of the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).(2)Serum inflammatory factor levels:Before treatment,there were no significant differences in the levels of procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)between the two groups(P>0.05);After treatment,the levels of serum inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).(3)Treatment effect:The treatment effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of human immunoglobulin combined with cefoperazone sodium and sulbactam sodium for injection in children with NIP can effectively shorten the times of dyspnea,cough disappearance,pulmonary rales disappearance,temperature stability and wheezing disappearance of children,regulate the levels of serum inflammatory factors.