亚高原地区成年人血清尿酸水平与高血压的关系研究

Study on the Relationship between Serum Uric Acid Level and Hypertension of Adults in Sub-altitude Areas

目的探讨亚高原地区成年人血清尿酸(uric acid,UA)水平与高血压的关系,为UA水平是否与亚高原地区高血压的发生和发展相关提供临床依据。方法本研究的数据来源于云南省一项横断面调查,根据高血压诊断标准将6183例调查对象分为正常血压组和高血压组,对两组间临床资料进行比较,并采用多元线性回归分析探讨UA水平与血压水平的相关性,构建Logistic回归分析模型探讨UA与高血压的关系。结果多元线性回归分析结果显示,当其他变量取值不变时,尿酸每增加1mg/dl,收缩压(systolic blood pressure,SBP)平均升高1.098mmHg(95%CI:0.810~1.387mmHg),舒张压(diastolic blood pressure,DBP)平均升高0.274mmHg(95%CI:0.085~0.462mmHg)。在调整其他混杂因素后,UA水平对高血压的影响差异有统计学意义(OR=1.128,95%CI:1.068~1.191,P<0.001),尿酸水平升高增加高血压的患病风险。结论UA水平越高,SBP水平、DBP水平、高血压患病风险越高,亚高原地区成年人血清UA水平升高可能与高血压的发生和发展相关。

Objective To investigate the association between serum uric acid(UA)level and hypertension among adults in sub-plateau regions,and to provide clinical evidence for whether UA level is associated with the occurrence and development of hypertension in sub-plateau regions.Methods According to the diagnostic criteria of hypertension,6183survey subjects were divided into normal blood pressure group and hypertension group.This study was derived from a cross-sectional survey in Yunnan Province.The clinical data between the two groups were compared,the multiple linear regression analysis was used to explore the correlation between UA level and blood pressure level,and the Logistic regression analysis model was constructed to explore the relationship between UA and hypertension.Results The results of multiple linear regression analysis showed that when other variables remained unchanged,the average increase of uric acid by 1mg/dl was 1.098mmHg in SBP(95%CI:0.810-1.387)and that of DBP was 0.274mmHg(95%CI:0.085-0.462 mmHg).Logistic regression analysis showed that after adjusting for other confounding factors,UA level had a statistically significant effect on hypertension(OR=1.128,95%CI:1.068-1.191,P<0.001),and elevated uric acid level increased the risk of hypertension.Conclusion The higher of UA level,the higher the SBP level,DBP level and the risk of hypertension.The increase of serum UA level in adults in sub-plateau areas may be related to the occurrence and development of hypertension.