多房棘球蚴病相关细胞信号通路的研究进展

Research progress on the cellular signal pathways associated in alveolar echinococcosis

多房棘球蚴病(AE)是一种在北半球高纬度地区流行、危害程度高的人兽共患寄生虫病。AE通常原发于肝组织,多房棘球蚴在患者体内呈浸润性生长,对累及脏器的形态及生理功能造成严重损伤。研究表明,多房棘球蚴及生发层细胞的增殖、机体免疫应答及免疫细胞的分化均与丝裂素原活化蛋白激酶(MAPK)、胰岛素(insulin,Ins)、程序性死亡受体-1(PD-1)、生长转化因子-β(TGF-β)等细胞信号通路有较为密切的联系。本文从相关细胞信号通路在多房棘球蚴病中对多房棘球蚴及宿主产生的免疫调节作一综述。

Alveolar echinococcosis(AE)is a highly harmful zoonotic parasitic disease,which is prevalent in the high latitudes of the northern hemisphere.AE usually occurs in liver tissue and Echinococcus grows infiltratively in patients.It can cause serious damage to the morphology and physiological function of the involved organs.In this process,the cellular signaling pathway is closely related to the course of AE.Cell signaling pathways,such as the mitogen-activated protein kinases(MAPK)pathway,insulin(Ins)pathway,programmed cell death protein 1(PD-1)pathway and transforming growth factorβ(TGF-β)pathway,are closely related to proliferation of Echinococcus,body immune response and differentiation of immune cells.This article has reviewed the role of related cellular signaling pathways in the immune regulation of alveolar echinococcosis and host in the process of AE infection.