草酸艾司西酞普兰联合早期主动运动康复训练在急性缺血性脑卒患者中的应用效果分析

Application Effect Analysis of Escitalopram Oxalate Combined with Early Active Exercise Rehabilitation Training in Patients with Acute Ischemic Stroke

目的:探讨草酸艾司西酞普兰联合早期主动运动康复训练在急性缺血性脑卒中患者中的应用效果。方法:选取2021年10月—2022年12月枣庄市立第四医院收治的82例急性缺血性脑卒中患者作为研究对象,依据随机数字表法分为观察组与对照组,各41例。对照组给予常规治疗联合早期主动运动康复训练,观察组在对照组基础上应用草酸艾司西酞普兰治疗。比较两组生活质量、神经功能、去甲肾上腺素(NE)及5-羟色胺(5-HT)水平、不良反应发生情况。结果:治疗前,两组改良Barthel指数(MBI)、美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后,观察组MBI评分高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.001)。治疗前,两组NE、5-HT水平比较,差异无统计意义(P>0.05);治疗后,观察组NE、5-HT水平高于对照组,差异有统计学意义(P<0.001)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:急性缺血性脑卒中患者采用草酸艾司西酞普兰联合早期主动运动康复训练治疗,可明显改善其生活质量、神经功能、抑郁相关血清指标,且治疗安全性较高。

Objective:To explore the application effect of escitalopram oxalate combined with early active exercise rehabilitation training in patients with acute ischemic stroke.Method:A total of 82 patients with acute ischemic stroke admitted to Zaozhuang Fourth Hospital from October 2021 to December 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 41 cases in each group.The control group was given conventional treatment combined with early active exercise rehabilitation training and the observation group was given escitalopram oxalate treatment on the basis of control group.Quality of life,neurological function,norepinephrine(NE)and 5-hydroxytryptamine(5-HT)level,and the incidence of adverse reactions in the two groups were compared.Results:Before treatment,there was no significant difference in modified Barthel index(MBI)and National Institutes of Health Stroke Scale(NIHSS)scores between the two groups(P>0.05).After treatment,the MBI score in the observation group was higher than that in the control group,and the NIHSS score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in NE and 5-HT levels between the two groups(P>0.05).After treatment,the levels of NE and 5-HT in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Escitalopram oxalate combined with early active exercise rehabilitation training in patients with acute ischemic stroke can significantly improve the quality of life,neurological function and depression-related serum indicators,with high therapeutic safety.