唑来膦酸联合钙剂治疗原发性骨质疏松的临床疗效

Clinical efficacy of zoledronic acid combined with calcium in the treatment of primary osteoporosis

目的探究唑来膦酸联合钙剂治疗原发性骨质疏松(OP)的临床疗效。方法选择180例OP患者,并平均随机分为研究组和对照组。对两组患者均给与口服碳酸钙D3片(Ⅱ),在此基础上研究组患者合并接受唑来膦酸注射治疗,治疗12个月后观察临床疗效并统计总有效率。采集所有患者在治疗前和治疗后的骨密度,疼痛视觉模拟评分(VAS),以及骨生化指标,包括血钙(Ca)、血磷(P)、骨γ-羧基谷氨酸蛋白(BGP)和降钙素(hCT)、Ⅰ型胶原氨基端肽(P1NP)和Ⅰ型胶原交联羧基末端肽(β特异性序列)(β-CTX)。结果研究组的临床疗效好于对照组(P<0.05)。治疗后,研究组患者的骨密度高于对照组(P<0.05),VAS评分低于对照组(P<0.05)。治疗后,对照组和研究组的血钙、血磷和BGP的差异不显著(均P>0.05),研究组的hCT和P1NP水平高于治疗前(均P<0.01),β-CTX水平低于治疗前(P<0.01)。结论唑来膦酸联合钙剂对OP具有较好的治疗效果。

Objective To investigate the clinical efficacy of zoledronic acid combined with calcium in the treatment of primary osteoporosis(OP).Methods A total of 180 patients with OP were selected and randomly divided into study group and control group.The two groups of patients were given oral calcium carbonate D3 tablets(Ⅱ),on this basis,the patients in the study group were given zoledronic acid injection.The clinical efficacy was observed after 12 months of the treatment,and the total effective rate was calculated.The bone mineral density,visual analog scale(VAS)of pain,and bone biochemical indexes,including blood calcium(Ca),blood phosphorus(P),boneγ-carboxyglutamate protein(BGP),calcitonin(hCT),collagen type I amino-terminal peptide(P1NP)and collagen type I cross-linked carboxy-terminal peptide(β-specific sequence)(β-CTX)were collected before and after the treatment.Results The clinical efficacy of the study group was better than that of the control group(P<0.05).After the treatment,the bone mineral density in the study group was higher(P<0.05),and the VAS score was lower than that in the control group(P<0.05).After the treatment,there was no significant difference in serum calcium,serum phosphorus and BGP between the control group and the study group(all P>0.05),the hCT and P1NP levels in the study group were significantly higher than those before the treatment(all P<0.01),and theβ-CTX level was significantly lower than that before the treatment(P<0.01).Conclusions Zoledronic acid combined with calcium has a good therapeutic effect on OP.