miRNA在缺血性脑卒中危险因素中表达的研究进展

Research progress of miRNA in ischemic stroke-related risk factors

脑卒中是目前引起全球人口死亡和导致长期致残的重要原因,缺血性脑卒中的发生率、致残率和死亡率均较高,给社会和家庭均带来沉重负担。微小核糖核酸(miRNA)参与多种生物学过程,如增殖、分化、代谢、突触形成、血管新生和细胞凋亡等,在脑血管病的危险因素中发挥着不可或缺的调节作用。其可能成为缺血性脑卒中快速诊断和治疗效果评价的重要生物标志物,对缺血性脑卒中危险因素的干预提供了预防途径。主要综述miRNA在缺血性脑卒中危险因素如高血压、糖尿病、冠心病、动脉粥样硬化和颈动脉狭窄等中表达的研究进展,以期对疾病的预防和诊治提供新的思路。

Stroke is an important cause of global population death and long-term disability.The incidence,disability,and mortality of ischemic stroke are high,which brings a heavy social and economic burden to society and families.MiRNA is involved in a variety of biological processes,such as proliferation,differentiation,metabolism,synaptic formation,angiogenesis,apoptosis,and so on.MiRNA plays an indispensable regulatory role in the risk factors of a variety of cerebrovascular diseases.In particular,some circulating miRNA have significant changes in the peripheral blood of patients with acute stroke,which may become an important biomarker for rapid diagnosis and treatment of stroke.Intervention on stroke risk factors provides an important way for the prevention of cerebrovascular disease.In this review,the studies on the expression and mechanism of miRNA related to common stroke risk factors,including hypertension,diabetes,coronary heart disease,atherosclerosis,carotid stenosis,depression,age,and stimulating hormones,were summarized to provide new ideas for disease prevention and diagnosis.