pH响应型过氧化铜修饰的介孔二氧化硅纳米催化剂用于肿瘤治疗

pH-responsive Copper Peroxide Coated Mesoporous Silicon Nanocatalyst for Tumor Therapy

化疗是目前癌症治疗中最主要的治疗手段,然而化疗药物对肿瘤细胞无选择性,使得药物进入生物体后分布于各个组织器官,只有少量药物到达肿瘤组织,毒副作用大,治疗效果不尽人意。基于此,合成了一种负载过氧化铜(CuO2)的介孔二氧化硅(MSN)纳米催化剂,其内部装载化疗药物阿霉素(DOX),表面负载CuO2封堵孔道,避免药物提前释药,同时CuO2在胞内酸性条件下可通过类芬顿反应协同化疗杀死癌细胞,提高抗肿瘤疗效;实验数据显示,载药颗粒为146.2 nm的规则球形,比表面积458.07 m2/g,载药量为14.9%。本研究为肿瘤的联合治疗提供了一种新的策略。

Chemotherapy is the main method in the tumor treatment at present.However,chemotherapeutic drugs have no selectivity for tumor cells.After entering the organism,drugs will be distributed in the normal organs and only a few of drugs could reach the tumor tissues,which shows terrible side effect and poor therapeutic effect.Here,we synthesize a copper peroxide(CuO_(2))coated mesoporous silicon nanoparticle(MSN),in which doxorubicin(DOX)is loaded into the pore,and CuO2 is coated on the surface of MSN to prevent the premature of drug release.Meanwhile,CuO2 can be decomposed in low pH condition and kill the cancer cells through the Fenton-like reaction with the combination of chemotherapy to improve the anti-tumor effect.The experimental data show that the drug-loaded particles are 146.2 nm spherical,with a specific surface area of 458.07 m^(2)/g and a drug load of 14.9%.This study provides a new strategy for synergistic tumor therapy.