肠道菌群与抗结核药及其所致肝损伤的相关性研究进展

Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury

结核病是结核分枝杆菌引起的严重危害人类健康的慢性传染病,有效的抗结核治疗是遏制其流行的关键。肠道菌群作为人类“第二基因组”,其稳态对维持人体健康十分重要。抗结核药物属于抗生素类药品,可导致肠道菌群的失衡,失衡的肠道菌群又与抗结核药物性肝损伤密切相关,并可影响治疗的效果与疾病的转归。笔者主要就抗结核药对肠道菌群的影响、抗结核药所致肠道菌群失调与肝损伤、肠道菌群的改变对宿主的影响3个方面进行综述。

The bacteria mycobacterium tuberculosis is the primary cause of tuberculosis,a deadly chronic infectious disease.Effective antituberculous therapy is essential for controlling the tuberculosis epidemic.Since the intestinal flora serves as the"second genome"of humans,maintaining its equilibrium is critical for maintaining good health.Antibiotics,which are commonly used to treat tuberculosis,may disturb the equilibrium of the intestinal flora.Intestinal flora imbalance has been linked to liver damage caused by antituberculosis drugs,and it can influence how well treatments work and how the disease develops.This paper discusses the impact of antituberculosis medications on intestinal flora,the imbalance of intestinal flora and liver damage caused by antituberculosis medications,and the repercussions of changes in intestinal flora on the host.