线粒体与椎间盘退变

Mitochondrial and intervertebral disc degeneration

腰痛已成为全球范围内致残的首要原因,且发病率逐年上升。椎间盘退变(IVDD)是腰痛的主要致病因素,但其病理机制尚未明确。线粒体是生物体内产能的重要细胞器,不仅在生理过程中承担重要作用,还参与诸多关节退行性疾病的病理过程,但线粒体参与椎间盘退变的机制尚未阐明。本文对近年来线粒体参与IVDD机制及相应治疗策略的研究进展综述。

Low back pain has become the leading cause of disability in worldwide,and the incidence is increasing year by year.Intervertebral disc degeneration(IVDD)is the main causative factor of low back pain,but its pathological mechanism is not well understood.Mitochondria are important organelles for energy production in organisms,not only playing an important role in physiological processes,but also participating in the pathological processes of many joint degenerative diseases.However,the mechanism of mitochondrial participation in intervertebral disc degeneration has not yet been elucidated,and this article reviews the research progress of mitochondria in IVDD and corresponding treatment strategies in recent years by reviewing relevant literature.