儿童肥胖与阻塞性睡眠呼吸暂停的相关性研究进展

Research progress on correlation between childhood obesity and obstructive sleep apnea

儿童肥胖的患病率正在逐渐增加,在世界范围内女童的肥胖患病率为5.6%,男童为7.8%。这同时导致肥胖相关疾病发病率也相应增加,尤其是阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)。肥胖是儿童OSA的独立危险因素和调节因子。儿童OSA和肥胖之间存在一种双向因果关系。在儿童OSA和肥胖之间的联系中,涉及的因素包括炎症反应、氧化应激和肠道菌群等。然而,肥胖相关的炎症反应与OSA发病机制之间的因果关系仍需进一步研究,本综述就儿童肥胖与OSA的相关性进行探讨。

Prevalence of childhood obesity is progressively increasing,reaching worldwide levels of 5.6%in girls and of 7.8%in boys.This also leads to a corresponding increase in the prevalence of obesity-associated morbidities particularly those involving obstructive sleep apnea(OSA).Obesity is an independent risk factor and regulator of OSA in children.There is a bidirectional causal relationship between OSA and obesity in children.The factors involved in the association between OSA and obesity are systemic inflammation,oxidative stress,and gut microbiota etc.However,a causal link between obesity-related inflammatory state and OSA pathogenesis still needs to be properly confirmed.The present review aimed to investigate the links between childhood obesity and OSA.