摘要
肠道屏障不仅是肠道选择性消化吸收营养物质的结构基础,也是肠道不断接受外界刺激的保护性屏障。丁酸钠能够通过调控组蛋白乙酰化、G蛋白偶联受体等多条途径,保持肠道黏膜上皮完整,增强肠道免疫功能,降低肠道炎症水平和维持肠道菌群平衡等,发挥抗病促生长的作用。本文综述了丁酸钠调控肠道屏障的作用机制及其在肉鸡养殖中的应用,以期为丁酸钠在肉鸡营养上发挥替抗作用提供参考。
The intestinal barrier is not only a structural basis for selective digestion and absorption of nutrients,but also a protective barrier for the intestinal tract to continuously receive external stimuli.Sodium butyrate can maintain the integrity of intestinal mucosal epithelium,enhance intestinal immune function,reduce intestinal inflammation and maintain intestinal microbiota balance by regulating histone acetylation,G protein-coupled receptor and other pathways,so as to play the role of disease resistance and growth promotion.This review summarized the mechanism of sodium butyrate regulating intestinal barrier and its application in broiler breeding,in order to provide references for sodium butyrate to replace antibiotics in broiler nutrition.
作者
王宗伟
庄佳荣
李洪涛
赵旭
WANG Zongwei;ZHUANG Jiarong;LI Hongtao;ZHAO Xu(College of Agriculture and Forestry Science,Linyi University,Linyi 276000,China;Shouguang Government Service Center,Shouguang 262700,China;Linyi Backbone Biotechnology Co.,Ltd.,Linyi 276036,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2023年第5期2729-2737,共9页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
山东省重点研发计划(重大科技创新工程)项目(2019JZZY020609)
临沂大学高层次人才科研启动项目(LYDX2019BS036)。
关键词
丁酸钠
肠道屏障
肉鸡
炎症
促生长
sodium butyrate
intestinal barrier
broilers
inflammation
growth promotion
