含吲哚骨架的磷酰亚甲基衍生物的构建新策略

A New Strategy for the Construction of Phosphoyl Methylene Derivatives Containing Indole Skeletons

在碱催化作用下,成功实现了吲哚烯酰基化合物与二苯基氧膦P—H键的加成反应,并通过对催化剂、反应溶剂、反应时间、催化剂用量等影响因素的筛选,探索了优化的反应条件。在优化条件下催化合成了一系列含吲哚骨架的磷酰亚甲基化合物,获得了较好的产率。该反应条件温和、产率高、反应迅速,为C(sp^(3))—P键的构筑提供了一种绿色高效的新方法。

We have successfully obtained a series of phosphoryl methylene compounds containing indole skeleton by addition reaction between indole enoyl compounds and diphenylphosphine oxide in the presence of base.Through the selection of catalyst,reaction solvent,temperature,catalyst dosage and other factors,the optimum reaction conditions were obtained.The excellent yield were achieved under optimal conditions.The method exhibits many advantages such as low temperature,high yield,rapid response and so on.A new green and effective method for the construction of C(sp^(3))-P bond is developed.