乙型肝炎疫苗初次免疫低/无应答婴儿再免后的免疫记忆持久性随访观察

Persistence follow-up of immune memory to hepatitis B vaccine among infants with non- and low-response to primary vaccination after revaccination with three doses

本研究对乙型肝炎疫苗(HepB)初次免疫低/无应答婴儿再次免疫后的免疫记忆进行了随访观察,最终将随访时抗-HBs<10 mIU/ml(抗-HBs阴性)且未进行自行加强免疫的120名儿童纳入研究,其中有86名儿童完成采血和抗-HBs检测。接种激发剂次前,86名儿童抗-HBs全部阴性,抗-HBs的GMC均<10 mIU/ml;激发剂次接种后,抗-HBs阳转率为100%,抗-HBs的GMC为886.11(95%CI:678.15~1157.84)mIU/ml。与接种激发剂次前抗-HBs<4 mIU/ml者相比,抗-HBs>7 mIU/ml者接种激发剂次后的抗-HBs水平较高,β(95%CI)值为0.82(0.18~1.46)(P=0.012);与初次免疫后抗-HBs<1000 mIU/ml者相比,初次免疫后抗-HBs≥1000 mIU/ml者接种激发剂次后的抗-HBs水平较高,β(95%CI)值为0.78(0.18~1.38)(P=0.012)。结果提示,HepB初次免疫低/无应答婴儿再次免疫9年后仍存在较强免疫记忆。

This study followed up the immune memory after 3-dose revaccination among infants with non-and low-response following primary hepatitis B(HepB)vaccination.About 120 children without self-booster doses were finally included who had anti-HBs<10 mIU/ml(anti-HBs negative)at the time of follow-up,of whom 86 children completed blood sampling and anti-HBs testing.Before the challenge dose,all 86 children were negative for anti-HBs,and the GMC of anti-HBs was<10 mIU/ml.The seropositive conversion rate of anti-HBs was 100%and the GMC of anti-HBs was 886.11(95%CI:678.15-1157.84)mIU/ml after the challenge dose.Compared with those with GMC<7 mIU/ml before the challenge dose,infants with GMC>7 mIU/ml had a higher anti-HBs level after the challenge dose.Theβvalue(95%CI)was 0.82(0.18-1.46)(P=0.012).Compared with those with GMC<1000 mIU/ml at primary vaccination,infants with GMC≥1000 mIU/ml had a higher anti-HBs level after the challenge dose.Theβvalue(95%CI)was 0.78(0.18-1.38)(P=0.012).The results showed a stronger immune memory was found at 9 years after revaccination among infants with non-and low-response to HepB.