转化生长因子β在肿瘤微环境中的作用及其靶向药物研究进展

The role of transforming growth factor-βin tumor microenvironment and research progress of its targeting drugs

转化生长因子β (transforming growth factor-β,TGF-β)是一种多效性细胞因子,属于调节细胞生长和分化的TGF-β超家族。在肿瘤发展的后期,自分泌和旁分泌的TGF-β可能通过诱导上皮-间质转化、促进肿瘤血管生成、调节免疫抑制来调控肿瘤的转移和复发。因此,TGF-β被认为是晚期肿瘤生长、进展和转移潜能的重要因素。中和或阻断TGF-β是一种干预和干扰肿瘤生长关键启动子的独特方法,可能会提供一个新的治疗机会。此文就TGF-β的结构、功能及其在肿瘤微环境中的作用机制进行综述,并列举了一些在研的靶向TGF-β药物,旨在为抗肿瘤药物的开发和临床应用提供参考。

Transforming growth factor-β(TGF-β)is a pleiotropic cytokine which belongs to the TGF-βsuperfamily that regulates cell growth and differentiation.In the later stages of tumor development,TGF-βmay regulate tumor metastasis and recurrence by inducing epithelial-mesenchymal transition,promoting tumor angiogenesis and regulating immunosuppression through autocrine and paracrine effects.Therefore,TGF-βhas been implicated as an important factor in the growth,progression,and metastatic potential of advanced cancers.Neutralizing or blocking TGF-βrepresents a unique method of intervening and disrupting a key promoter of tumor growth and may provide a new therapeutic opportunity.This review discusses the structure,function and mechanism of TGF-βin tumor microenvironment,and lists some drugs targeting TGF-β,aiming to provide reference for the development and clinical application of anti-tumor drugs.