子宫内膜类器官研究进展

Research advances in endometrial organoids

子宫内膜类器官(endometrial organoids,EOs)是子宫内膜细胞自组织的三维聚集物,代表子宫内膜的结构和功能。根据所包含的细胞类型的数量,EOs可分为两类:单种细胞EOs和多种细胞EOs。EOs将加速我们对子宫内膜发育和疾病的分子和细胞机制的理解,将成为从疾病建模到个性化医疗等生物医学应用的有前途的工具。本文对EOs的表型(典型的表面标记和结构)、遗传特征、培养基、对激素的反应、模拟的疾病模型、挑战和未来展望逐一综述。

Endometrial organoids(EOs)are three-dimensional aggregates of endometrial cells,which represent the structure and function of endometrium.According to the number of cell types contained,EOs can be divided into two categories,single-cell EOs and multicellular EOs.EOs will accelerate our understanding of the molecular and cellular mechanisms of endometrial development and diseases,and will become a promising tool for biomedical applications from disease modeling to personalized medicine.This review described the phenotype(typical surface markers and structure),genetic characteristics,culture medium,response to hormones,simulated disease model,challenges and future prospects of EOS.