组蛋白H2BK在胶质瘤中的表达及其临床意义

Expression and significance of histone H2BK in glioma

目的探讨胶质瘤组织中组蛋白H2BK(HIST1H2BK)表达与临床特征和预后的关系。方法选取北海市第二人民医院和广西医科大学附属肿瘤医院86例接受手术治疗的胶质瘤病例资料,免疫组织化学分析不同病理级别胶质瘤H2BK的表达,评估H2BK表达与临床病理的关系。生存分析研究H2BK对胶质瘤预后的影响。结果高级别胶质瘤组织中H2BK的表达率(82.22%)明显高于低级别胶质瘤(14.63%)。术后随访1~60个月,死亡71例。多因素Cox回归分析显示,H2BK高表达[风险比(HR)=0.393,95%可信区间(CI):0.224~0.688,P<0.01]是胶质瘤病人总生存期(OS)和无进展生存期(PFS)不良的独立危险因素(P<0.05)。生存曲线分析显示,H2BK高表达胶质瘤病人中位OS、PFS较低表达病人明显缩短(χ^(2)=15.092,P<0.05)。结论高级别胶质瘤中H2BK高表达与胶质瘤患者不良生存预后呈负相关。

Objective To investigate the relationship between the expression of histone H2BK(HIST1H2BK)and clinical characteristics and prognosis in glioma.Methods The 86 gliomas cases data treated by surgery were selected from two hospital.The expression of H2BK in gliomas of different pathological grades was analyzed by immunohistochemistry,and the relationship between the expression of H2BK and clinical pathology was evaluated.The survival analysis was used to study the effect of H2BK on the prognosis of glioma.Results The expression rate of H2BK in high-grade gliomas(82.22%)was significantly higher than that in low-grade gliomas(14.63%).A total of 71 cases died after follow-up for 1 to 60 months.Multivariate Cox regression analysis showed that the high expression of H2BK(HR=0.393,95%CI:0.224-0.688,P<0.01)was an independent risk factor for poor overall survival(OS)and progression-free survival(PFS)in glioma patients(P<0.05).The survival curve analysis showed that the median OS and PFS of patients with high expression of H2BK were significantly shorter than those with low expression of H2BK(χ^(2)=15.092,P<0.05).Conclusion The high expression of H2BK in high-grade gliomas is negatively correlated with the poor survival and prognosis of gliomas.