环状RNA在胃癌诊断治疗中的研究进展

Research progress of circular RNA in diagnosis and treatment of gastric cancer

近年来,利用高通量测序技术在胃癌组织内检测且经过生物学功能验证发现,与胃癌作用机制密切相关的环状RNA种类不断增加。环状RNA已被证实具有调控胃癌相关基因、作为基因转录蛋白质和成为微小RNA的分子海绵调控基因表达等多种功能,因此环状RNA毫无疑问参与调控胃癌细胞的发生发展、免疫逃逸、迁移侵袭等过程。环状RNA的结构特异性和生物学稳定性使其有望成为肿瘤诊断的潜在生物标志物。本文总结了环状RNA的产生、特性和分子生物学功能,并讨论了环状RNA在胃癌诊断和治疗中的潜在作用。

In recent years,the use of high-throughput sequencing technology in gastric cancer(GC)tissue detection and biological function verification found that the types of circular RNAs(circRNAs)closely related to the mechanism of GC have been increasing.Circular RNAs have been confirmed to have various functions such as regulating GC-related genes,acting as gene transcription proteins,and regulating gene expression as molecular sponges of microRNAs(miRNAs).Therefore,circRNAs are undoubtedly involved in regulating the occurrence and development of GC cells,escape,migration and invasion.The structural specificity and biological stability of circRNA make it a potential biomarker for tumor diagnosis.This article summarizes the generation,properties,and molecular biological functions of circRNAs,and discusses the potential roles of circRNAs in the diagnosis and treatment of GC.