摘要
Immune rejection, poor biocompatibility and cytotoxicity have seriously stalled the widespread application of biometallic materials. To overcome these problems, biometallic materials with fast and sufficient osseointegration, antibacterial properties and long-term stability have attracted the attention of researchers worldwide. Surface modification is currently used as a general strategy to develop material coatings that will overcome these challenging requirements and achieve the successful performance of implants. In this study, we proposed a substrate surface-modification strategy based on biofilm Csg A proteins that promote rapid cell attachment, proliferation, and stabilization of the cytoskeleton. Csg A-based nano-coating is easy to fabricate and has superior performance, which is expected to expand the application of medical implants.
基金
supported by the National Natural Science Foundation of China (Nos. 82104477, U19A2010, and 81891012)
special support from China Postdoctoral Science Foundation(Nos. 2019M663456 and 2019TQ0044)
Xinglin Scholar Research Promotion Project of Chengdu University of TCM (No.BSH_(2)019008)
National Interdisciplinary Innovation Team of Traditional Chinese Medicine (No. ZYYCXTD-D-202209)
the Macao Science and Technology Development Fund (No. FDCT 007/2020/ALC)
the Shenzhen-Hong Kong-Macao S&T Program (Category C)(No. SGDX2020110309420200)
the Research Fund of University of Macao (No. CPG2022-00005-ICMS)。
