摘要
On-resin peptide modification renders an easy-to-operate method that combines solid-phase peptide synthesis efficiency and avoids tedious purification procedures. Herein, we report the transition-metal-free and redox-neutral approach for solid-phase Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides of different sizes.
基金
financial supported by the National Natural Science Foundation of China (No. 22077144)
Guangdong Natural Science Funds for Distinguished Young Scholar (No.2018B030306017)
Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (No. 2019B030301005)
Key Research and Development Program of Guangdong Province (No.2020B1111110003)。
